Renal-Cerebral Pathophysiology: The Interplay Between Chronic Kidney Disease and Cerebrovascular Disease.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
Ramy M HannaKamyar Kalantar-Zadeh

Abstract

Cerebrovascular disease has increasingly been linked to overall vascular health. Pathologic conditions like diabetes, hypertension, and kidney disease have been shown to affect brain health and cerebrovascular and nervous systems. Acute kidney injury (AKI) and chronic Kidney Disease (CKD) represent a variety of vascular insults that can adversely affect cerebral health. Hypertension, fluctuations in blood pressure, and diabetic vasculopathy are known risk factors for cerebrovascular disease associated with CKD. Other emerging areas of interest include endothelial dysfunction, vascular calcification due to calcium and phosphorus metabolism dysregulation, and uremic neuropathy present the next frontier of investigation in CKD and cerebrovascular health. It has become apparent that the interrelation of AKI and CKD with vascular health, chemical homeostasis, and hormonal regulation upset many aspects of cerebral health and functioning. Stroke is an obvious connection, with CKD patients demonstrating a higher proclivity for cerebrovascular accidents. Cerebral bleeding risk, uremic neuropathies, sodium dysregulation with impacts on nervous system, vascular calcification, and endothelial dysfunction are the next salient areas of resea...Continue Reading

References

Apr 15, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M J Sarnak, A S Levey
May 25, 2001·Journal of the American Society of Nephrology : JASN
Apr 30, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Josef CoreshAndrew S Levey
Jun 26, 2002·Kidney International·Won K HanJoseph V Bonventre
Sep 24, 2004·The New England Journal of Medicine·Alan S GoChi-yuan Hsu
Dec 22, 2005·Journal of Neurosurgical Anesthesiology·Martin TisdallMartin Smith
Nov 6, 2007·Journal of the American Society of Nephrology : JASN·Heather N ReichUNKNOWN Toronto Glomerulonephritis Registry
Feb 7, 2008·Clinical Journal of the American Society of Nephrology : CJASN·George L Bakris
Sep 17, 2008·Clinical Nephrology·V Gärtner, T K Eigentler
Mar 20, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Wieneke Marleen MichelsRaymond Theodorus Krediet
Jul 14, 2010·Current Opinion in Nephrology and Hypertension·Robert D Toto
Jan 29, 2011·Cardiology Research and Practice·Masaki Mogi, Masatsugu Horiuchi
Mar 17, 2011·Advances in Chronic Kidney Disease·Chung-Yi ChengMohammed S Razzaque
Jan 24, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Kenn B DarathaKatherine R Tuttle
Jun 26, 2012·Current Vascular Pharmacology·Antonietta GiganteRosario Cianci
Jul 6, 2012·The New England Journal of Medicine·Lesley A InkerUNKNOWN CKD-EPI Investigators
Jul 11, 2012·Journal of Cachexia, Sarcopenia and Muscle·Sapna S PatelKamyar Kalantar-Zadeh
Sep 1, 2012·Journal of the American Society of Nephrology : JASN·Jodie L Babitt, Herbert Y Lin
Sep 15, 2012·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Naoki Kashihara
Mar 8, 2013·Seminars in Nephrology·Cortney Bosworth, Ian H de Boer
Apr 16, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Paulo W PiresAnne M Dorrance
May 25, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Michael G ShlipakCarmen A Peralta
May 25, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Andrew D Rule, Richard J Glassock
May 3, 2014·Kidney International·Mark E MolitchCarl E Mogensen
May 9, 2014·American Journal of Physiology. Renal Physiology·Shunsuke YamadaTakanari Kitazono
Jul 16, 2014·Kidney International Supplements·Francesco P Cappuccio
Jul 16, 2014·Kidney International Supplements·Paul E Drawz, Mark E Rosenberg
Nov 7, 2014·World Journal of Nephrology·G V Ramesh Prasad
Dec 3, 2014·Advances in Chronic Kidney Disease·Patrick H Pun
Dec 21, 2014·Journal of the American Society of Nephrology : JASN·Li FanLesley A Inker
Feb 11, 2015·World Journal of Nephrology·Salvador Lopez-Giacoman, Magdalena Madero
Mar 4, 2015·Nature Reviews. Nephrology·Connie M Rhee, Csaba P Kovesdy
Aug 25, 2015·Diabetes Spectrum : a Publication of the American Diabetes Association·Mark E Molitch
Sep 12, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jean-Marc ChillonBénédicte Stengel
Oct 21, 2015·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Shunsuke YamadaKazuhiko Tsuruya
Oct 31, 2015·Stroke; a Journal of Cerebral Circulation·Oh Young BangJong S Kim
Dec 9, 2015·Journal of the American Heart Association·Lara C KovellJohn W McEvoy
Aug 2, 2016·Clinical Kidney Journal·Ramy Magdy HannaJames Wilson
Aug 11, 2016·Stroke; a Journal of Cerebral Circulation·Shunsuke YamadaTakanari Kitazono
Sep 16, 2016·Translational Stroke Research·Wei Ling LauMark Fisher
Feb 1, 2013·Clinical Kidney Journal·José António Lopes, Sofia Jorge
Feb 12, 2017·Kidney International·Sjoerd A M E G TimmermansUNKNOWN Limburg Renal Registry
May 6, 2017·Current Osteoporosis Reports·Kathleen M Hill Gallant, David M Spiegel
May 30, 2017·Indian Journal of Nephrology·S Nayak-Rao, M P Shenoy
Jan 18, 2018·KI Reports·Fabrice Gankam Kengne, Guy Decaux
Jan 18, 2018·KI Reports·Marie MetzgerBénédicte Stengel

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