Renal changes and acute kidney injury in covid-19: a systematic review

Revista da Associação Médica Brasileira
Samuel Átila Rodrigues NogueiraMaria Elizabeth Pereira Nobre


We aimed to present a review of renal changes in patients with COVID-19. We performed a systematic review of the literature to identify original articles regarding clinical, laboratory, and anatomopathological kidney changes in patients infected with SARS-CoV-2 published until May 7, 2020. The search was carried out across PubMed, Scopus, and Embase using the keywords "COVID-19", "coronavirus", "SARS-CoV-2", "kidney injury" and "kidney disease". Fifteen studies presented clinical and laboratory renal changes in patients with COVID-19, and three addressed anatomopathological changes. Acute kidney injury (AKI) was a relevant finding in patients with COVID-19. There were also significant changes in laboratory tests that indicated kidney injury, such as increased serum creatinine and blood urea nitrogen (BUN), proteinuria, and hematuria. The presence of laboratory abnormalities and AKI were significant in severely ill patients. There was a considerable prevalence of AKI among groups of patients who died of COVID-19. Histopathological analysis of the kidney tissue of patients infected with SARS-CoV-2 suggested that the virus may directly affect the kidneys. Although COVID-19 affects mainly the lungs, it can also impact the kidneys. ...Continue Reading


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Nov 17, 2020·Journal of the American Geriatrics Society·Marcello CovinoUNKNOWN GEMELLI AGAINST COVID-19 Group
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