Renal clearance and daily excretion of cortisol and adrenal androgens in patients with rheumatoid arthritis and systemic lupus erythematosus

Annals of the Rheumatic Diseases
R H StraubJ Schedel

Abstract

In rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), patients demonstrate low levels of adrenal hormones. To investigate whether increased renal clearance and daily excretion contribute to this phenomenon. Thirty patients with RA, 32 with SLE, and 54 healthy subjects (HS) participated. Serum and urinary levels of cortisol, cortisone, 17-hydroxyprogesterone (17OHP), androstenedione, dehydroepiandrosterone (DHEA), and DHEA sulphate (DHEAS) were measured. Clearance of DHEAS and DHEA was lower in patients than in HS, and clearance of androstenedione was somewhat higher in patients than in HS, but daily excretion of this latter hormone was low. Clearance of cortisol, cortisone, and 17OHP was similar between the groups. The total molar amount per hour of excreted DHEA, DHEAS, and androstenedione was lower in patients than HS (but similar for cortisol). Serum DHEAS levels correlated with urinary DHEAS levels in HS and patients, whereby HS excreted 5-10 times more of this hormone than excreted by patients. Low serum levels of adrenal androgens and cortisol in patients as compared with HS were confirmed, and proteinuria was not associated with changes of measured renal parameters. This study in patients with RA and SLE d...Continue Reading

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Citations

Jan 11, 2012·Journal of Clinical Psychology in Medical Settings·Eric B Weiser
Mar 26, 2013·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Riley Bove
Nov 26, 2010·Rheumatic Diseases Clinics of North America·Richard Imrich, Jozef Rovenský
Jul 21, 2006·Annals of the New York Academy of Sciences·Martin SchmidtRainer H Straub
Oct 28, 2014·Analytical Chemistry·Hendrik NolteMarcus Krüger
May 1, 2008·Statistical Methods in Medical Research·David Afshartous, Richard A Preston
Jan 12, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Esin KasapSerkan Güçlü
Sep 14, 2016·The Journal of Clinical Endocrinology and Metabolism·Juilee RegeWilliam E Rainey
Aug 24, 2018·Environmental Health : a Global Access Science Source·Sipeng ShenDavid C Christiani
Mar 24, 2020·Genes and Immunity·Radomir M SlominskiAndrzej T Slominski
Oct 23, 2020·Modern Rheumatology Case Reports·Yoichi NakayamaNobuya Inagaki
Feb 9, 2021·Practical Laboratory Medicine·Karnpimon KrorakaiRina Patramanon

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