PMID: 8584482Oct 1, 1995Paper

Renal clearance of a recombinant granulocyte colony-stimulating factor, nartograstim, in rats

Pharmaceutical Research
T KuwabaraY Sugiyama

Abstract

To clarify the role of the kidney in the elimination of a recombinant human granulocyte colony-stimulating factor, nartograstim, we have investigated its pharmacokinetics in rats with renal failure. The steady-state clearance (CLss) were determined by the intravenous infusion for 4 hr to unilateral renally-ligated and cisplatin-treated rats, whose renal functions were about 50 and 10% of controls, respectively. CLss of nartograstim (27 ml/hr/kg) in the renally-ligated rats at a high infusion rate was significantly lower (25%) than in control rats (p < 0.05). CLss in these rats, at a low infusion rate was 95 ml/hr/kg, 14% lower than in control rats. The saturable CLss in these rats, 68 ml/hr/kg, was not significantly different from control rats (75 ml/hr/kg, p > 0.05). Also, CLss in cisplatin-treated rats with extensive renal failure, at a high infusion rate, decreased to 57% of controls. Furthermore, the total body clearances (CLtot) of nartograstim after bolus intravenous administration to renally-ligated and cisplatin-treated rats were reduced to 33-49% of controls. These results suggest that the kidney may be responsible for 40-50% of the nonsaturable clearance of nartograstim. Thus, the kidney should make a major contributi...Continue Reading

Citations

Aug 20, 2005·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Simon N RobinsonJames E Talmadge
Feb 21, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Y F LiJ J Kavanagh
Jul 19, 2012·World Journal of Microbiology & Biotechnology·F R GomesP L Ho
Dec 18, 2020·Frontiers in Bioengineering and Biotechnology·Monika KumariSonal Datta
May 16, 2021·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Claudio CerchioneGiovanni Martinelli

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