Renal concentration of alpha-tocopherol: dependence on gender and lack of effect on polycystic kidney disease in Han:SPRD rats

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
V E TorresP A Low

Abstract

A gender-associated dimorphism, with males being more severely affected than females, has been observed in autosomal dominant polycystic kidney disease, acquired renal cystic disease, and the renal cystic disease of the Han:SPRD rat. A recent study has suggested that gonadal hormones may be responsible for this dimorphism. Because gonadal hormones have an effect on the concentration of alpha-tocopherol in the liver and adrenal glands and because recent studies indicate that oxidative stress may be important in the pathogenesis of polycystic kidney disease, we wanted to determine whether the renal concentration of alpha-tocopherol is higher in female than in male rats and whether this difference accounts for the gender dimorphism of polycystic kidney disease in Han:SPRD rats. At 3 weeks of age, male and female heterozygous cystic (cy/+) rats were divided into three groups fed a vitamin E-deficient diet or the same diet supplemented with either 65 IU or 10,000 IU alpha-tocopherol/kg laboratory chow. At 8 weeks of age, blood samples and kidneys were obtained for determinations of plasma creatinine and urea, renal concentration of alpha-tocopherol and glutathione, kidney weights, and histomorphometric analysis. Female rats had high...Continue Reading

Citations

Dec 14, 2011·American Journal of Physiology. Renal Physiology·Sharon AndersonRadko Komers
Mar 29, 2002·Kidney International·Tevfik EcderCharles L Edelstein
Oct 23, 2004·Genomics·Hervé HussonOxana Ibraghimov-Beskrovnaya
Feb 14, 2015·Clinical and Experimental Pharmacology & Physiology·Thamarasee M JeewandaraJacqueline K Phillips
Mar 26, 2002·Journal of the American Society of Nephrology : JASN·Robin L MaserJames P Calvet
May 31, 2001·Kidney International·Q QianV E Torres
Sep 17, 2005·Kidney International·Kenneth D StringerSharon Anderson
Feb 17, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S NagaoJ J Grantham
Jun 10, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·I IshikawaY Kawaguchi

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