Renal deficiency associated with diabetes insipidus in the SWR/J mouse.

Physiology & Behavior
C L KutscherN L Schmalbach

Abstract

The age-dependent polydipsia and polyuria observed in SWR/J mice was found to be caused by relative inability of the kidneys to respond to antidiuretic hormone (ADH), resulting in a concentrating defect, which persisted even following Pitressin injection or water deprivation. Posterior pituitaries contained large amounts of ADH, which was also found in the urine and increased in output following water deprivation, indicating normal, or above normal synthesis and release of ADH. Kidneys of polydipsic SWR/J mice weighed more than those of normal strains and sometimes contained a lesion in the medullary area. No clear relationship was found between the size of the lesion and water intake.

References

Jul 1, 1974·Physiology & Behavior·C L Kutscher, D G Miller
May 1, 1967·The American Journal of Medicine·R W Berliner, C M Bennett

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Citations

Jan 1, 1980·Journal of Inherited Metabolic Disease·G Bulfield
Feb 1, 1976·Pharmacology, Biochemistry, and Behavior·N L Schmalbach, C L Kutscher
Jul 27, 2000·Molecular and Cellular Biology·H T HoS S Chung
Dec 1, 1977·Canadian Journal of Genetics and Cytology. Journal Canadien De Génétique Et De Cytologie·N S Virgo, J R Miller
Nov 13, 2019·Current Osteoporosis Reports·Sashank LekkalaEve Donnelly
Jul 18, 2000·American Journal of Physiology. Cell Physiology·S Rao, A S Verkman
Oct 3, 2018·Aging and Disease·Stefanie HardtIrmgard Tegeder
Jul 28, 2020·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Wing Yip Tam, Kwok-Kuen Cheung
Jun 15, 2021·Frontiers in Cellular and Infection Microbiology·Benjamin O MurrayJennifer L Rohn

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