Renal Denervation in High-Risk Patients With Hypertension

Journal of the American College of Cardiology
Felix MahfoudMichael Böhm

Abstract

Renal denervation (RDN) is under investigation for treatment of uncontrolled hypertension and might represent an attractive treatment for patients with high cardiovascular (CV) risk. It is important to determine whether baseline CV risk affects the efficacy of RDN. The purpose of this study was to assess blood pressure (BP) reduction and event rates after RDN in patients with various comorbidities, testing the hypothesis that RDN is effective and durable in these high-risk populations. BP reduction and adverse events over 3 years were evaluated for several high-risk subgroups in the GSR (Global proSpective registrY for syMPathetic renaL denervatIon in seleCted IndicatIons Through 3 Years Registry), an international registry of RDN in patients with uncontrolled hypertension (n = 2,652). Comparisons were made for patients age ≥65 years versus age <65 years, with versus without isolated systolic hypertension, with versus without atrial fibrillation, and with versus without diabetes mellitus. Baseline cardiovascular risk was estimated using the American Heart Association (AHA)/American College of Cardiology (ACC) atherosclerosis cardiovascular disease (ASCVD) risk score. Reduction in 24-h systolic BP at 3 years was -8.9 ± 20.1 mm H...Continue Reading

Associated Clinical Trials

Citations

Nov 1, 2020·Current Hypertension Reports·Leslie Marisol Lugo-GavidiaMarkus P Schlaich
Feb 16, 2021·Progress in Cardiovascular Diseases·Lucas LauderFelix Mahfoud
Apr 2, 2021·Circulation Research·Felix MahfoudMelvin D Lobo
Apr 13, 2021·Advances in Therapy·Aileen KearneyIan B A Menown
May 19, 2021·ESC Heart Failure·Ana JorbenadzeStefan D Anker
May 7, 2021·Journal of the American College of Cardiology·Felix MahfoudMichael A Weber
Jun 13, 2020·Journal of the American College of Cardiology·Stephen C Textor
Jun 20, 2021·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Byeong-Keuk KimYangsoo Jang
Aug 4, 2021·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·David E KandzariEric Secemsky
Aug 7, 2021·Expert Review of Cardiovascular Therapy·Márcio Galindo KiuchiMarkus P Schlaich
Aug 14, 2021·Journal of the American Heart Association·Zbigniew KalarusKarl-Heinz Kuck
Jul 16, 2021·Journal of Hypertension·Roland E SchmiederUNKNOWN members of the ESH Working Group on Device-Based Treatment of Hypertension
Sep 4, 2021·Journal of the American College of Cardiology·Michael BöhmFelix Mahfoud
Nov 23, 2021·The Cochrane Database of Systematic Reviews·Anna PisanoDavide Bolignano
Dec 16, 2021·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Aikaterini DamianakiMichel Burnier
Dec 19, 2021·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kenichi KatsuradaKazuomi Kario
Jul 9, 2021·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Felix MahfoudAjay J Kirtane
Dec 26, 2021·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Tzung-Dau Wang
Jan 15, 2022·Der Internist·Kristina StriepeRoland Schmieder

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