PMID: 6397726Jan 1, 1984Paper

Renal disorders in the newborn infant

La Pediatria medica e chirurgica : Medical and surgical pediatrics
J P Guignard

Abstract

Perinatal anoxia, or postnatal hypoxemia, as seen during respiratory distress syndrome, profoundly affects renal function. Hypoxemic neonates present with decreased water excretion, impaired diluting ability, urine acidification, glomerular filtration rate and renal perfusion. Stimulation of the renin-angiotensin system may explain, at least in part, the pathogenesis of the hypoxemia-induced renal changes. The renal defects are reversible upon restoring normoxemia, extracellular fluid volume and cardiac output. The neonatal kidney can also be affected by iatrogenic manipulations. Drugs acting efficiently on several target-organs can profoundly impair renal function. Tolazoline, sometimes used as a pulmonary vasodilator in persistent pulmonary hypertension of the premature infant, can increase renal vascular resistance with consequent renal failure. Indomethacin, a prostaglandin-synthetase inhibitor used to medically close a patent ductus arteriosus, can depress glomerular filtration and water excretion in the newborn infant. Aminoglycosides are widely used in neonatology. They can easily accumulate in neonates whose GFR is low. Their nephrotoxicity may be lower in neonates than in adults, but is certainly not negligible. Experi...Continue Reading

Related Concepts

Related Feeds

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Related Papers

Biology of the Neonate
J P Guignard, J B Gouyon
Revue médicale de la Suisse romande
J P GuignardP Toth
Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
P Tóth-HeynJ P Guignard
La Pediatria medica e chirurgica : Medical and surgical pediatrics
J P Guignard
Developmental Pharmacology and Therapeutics
T JatonJ P Guignard
© 2021 Meta ULC. All rights reserved