Renal dopamine synthesis from precursors

American Journal of Hypertension
M BarthelmebsJ L Imbs

Abstract

In the Wistar rat in vivo L-dopa (10 mg/kg, subcutaneously) was shown to have the characteristics of a kidney-directed dopamine (DA) prodrug: two daily injections increased 24 h urinary DA excretion 450-fold but had no systemic effects on blood pressure and heart rate. In inactin-anesthesized rats, L-dopa increased natriuresis, diuresis and renal blood flow; these effects were linked to endorenal DA synthesis and to DA-1 receptor stimulation since they were suppressed by both carbidopa and SCH 23390. In the isolated perfused rat kidney, DA was synthesized from L-dopa with a greater yield than from gludopa. In nonfiltering kidneys, L-dopa metabolism was not limited when the access to dopa decarboxylase was restricted to the basolateral membrane. The same was not true for gludopa, for which the basolateral metabolism was low.

Citations

Jan 1, 1992·Clinical and Experimental Hypertension. Part A, Theory and Practice·C J Chen, M F Lokhandwala
Jun 1, 1995·Journal of Autonomic Pharmacology·S NowickiM M Elias
Jan 1, 1993·Fundamental & Clinical Pharmacology·M BarthelmebsJ L Imbs
Jan 1, 1991·Clinical and Experimental Hypertension. Part A, Theory and Practice·C J Chen, M F Lokhandwala
May 10, 2000·Clinical and Experimental Hypertension : CHE·D P O'Connell, A M Aherne

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