Renal dysfunction in acute stroke: an independent predictor of long-term all combined vascular events and overall mortality

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
George TsagalisKonstantinos Vemmos


Acute stroke is the third leading cause of death in western societies after ischemic heart disease and cancer. Although it is an emergency disease sharing the same atherosclerotic risk factors with ischemic heart disease, the association of renal function and stroke is poorly investigated. The present study aims at assessing renal function status in patients with acute stroke and investigate any prognostic significance on the outcome. This is a prospective study of hospitalized first-ever stroke patients over 10 years. The study population comprised 1350 patients admitted within 24 h from stroke onset and followed up for 1 to 120 months or until death. Patients were divided in 3 groups on the basis of the estimated Glomerular Filtration Rate (eGFR) that was calculated from the abbreviated equation of the Modification Diet for Renal Disease in ml/min/1.73 m(2) of body surface area: Group-A comprised patients who had eGFR > 60, group-B those with 30 <or= eGFR <or= 60 and group-C patients with eGFR < 30. Patients with Acute Kidney Injury (AKI) were excluded from the study. The main outcome measures were overall mortality and the composite new cardiovascular events (myocardial infarction, recurrent stroke, vascular death) among the...Continue Reading


Feb 1, 1991·Journal of Internal Medicine·P J Friedman
Nov 20, 1993·Lancet·A Laupacis
Mar 1, 1997·Stroke; a Journal of Cerebral Circulation·S G WannametheeI J Perry
Sep 17, 1998·The New England Journal of Medicine·C A HerzogA J Collins
Dec 16, 1998·Dementia and Geriatric Cognitive Disorders·R C Petersen
Jan 8, 2000·Stroke; a Journal of Cerebral Circulation·S KurodaG Kimura
Feb 25, 2000·Cerebrovascular Diseases·K N VemmosS Stamatelopoulos
Jun 10, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·G M ChertowB J McNeil
Oct 6, 2001·Stroke; a Journal of Cerebral Circulation·S E CapesH C Gerstein
Jun 8, 2002·Stroke; a Journal of Cerebral Circulation·Ronald S MacWalterRouling Chen
Aug 21, 2002·Circulation·Jassim Al SuwaidiPARAGON-A Investigators. Platelet IIb/IIIa Antagonism for the Reduction of Acute coronary syndrome events in a Global Organi
Oct 2, 2002·Annals of Internal Medicine·R Scott WrightAllan S Jaffe
Oct 15, 2003·Hypertension·Mahmood S Mozaffari, Stephen W Schaffer
Nov 12, 2003·The New England Journal of Medicine·Marc A PfefferValsartan in Acute Myocardial Infarction Trial Investigators
Apr 22, 2004·Journal of the American Society of Nephrology : JASN·Daniel E WeinerMark Sarnak
Sep 24, 2004·The New England Journal of Medicine·Nagesh S AnavekarMarc A Pfeffer
Oct 21, 2005·Journal of the American Society of Nephrology : JASN·Stephen L SeligerDavid S Siscovick
May 16, 2006·Journal of the American College of Cardiology·Grace L SmithHarlan M Krumholz
Mar 3, 2007·Critical Care : the Official Journal of the Critical Care Forum·Ravindra L MehtaAcute Kidney Injury Network
May 15, 2007·Stroke; a Journal of Cerebral Circulation·Ralph L Sacco
Jul 4, 2007·Circulation·Ernesto L SchiffrinJohannes F E Mann
Jul 20, 2007·European Journal of Clinical Investigation·Maria AlevizakiKonstantinos Vemmos
Sep 1, 2007·Journal of Hypertension·Giuseppe ManciaESH-ESC Task Force on the Management of Arterial Hypertension
Oct 27, 2007·Stroke; a Journal of Cerebral Circulation·Minesh KhatriCharles DeCarli
Nov 9, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Adrian CovicNorica Posta
Dec 1, 2007·Stroke; a Journal of Cerebral Circulation·M Arfan IkramMonique M B Breteler


Sep 28, 2013·European Journal of Internal Medicine·Tanja Hojs Fabjan, Radovan Hojs
Feb 20, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Adalbert Schiller, Adrian Covic
Jul 6, 2014·The New England Journal of Medicine·Lakhmir S ChawlaPaul L Kimmel
Dec 17, 2011·Scandinavian Journal of Urology and Nephrology·Diange LiuJingqun Shen
May 9, 2012·The American Journal of Medicine·Adnan I QureshiAntihypertensive Treatment of Acute Cerebral Hemorrhage Investigators
Mar 14, 2014·International Journal of Stroke : Official Journal of the International Stroke Society·Anne RowatMartin Dennis
May 9, 2012·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Fabio FabbianRoberto Manfredini
Jun 24, 2017·International Journal of Stroke : Official Journal of the International Stroke Society·Derek HaydenPeter J Kelly
Feb 23, 2013·Cerebrovascular Diseases·Jung-Gon LeeHye-Won Hwang
Jan 23, 2018·Journal of Atherosclerosis and Thrombosis·Aryandhito Widhi NugrohoKazuhiko Nozaki
Jul 4, 2018·The Journal of International Medical Research·Nobuo KajitaniJun Wada
Jul 25, 2018·Toxins·Maryam AssemLucie Hénaut
Jun 7, 2014·Journal of the American Heart Association·Bruce OvbiageleGregg C Fonarow
Aug 15, 2014·Stroke; a Journal of Cerebral Circulation·Yang LuoCNSR Investigators
Jun 23, 2012·Stroke; a Journal of Cerebral Circulation·Robert SteinickeGerhard Jan Jungehulsing
Jul 9, 2011·Stroke; a Journal of Cerebral Circulation·Jukka PutaalaTurgut Tatlisumak
Jul 31, 2010·Stroke; a Journal of Cerebral Circulation·Niku K J OksalaTimo Erkinjuntti
Sep 9, 2018·British Journal of Clinical Pharmacology·Charlotte K BillingtonPhilip M W Bath
Dec 21, 2018·Stroke; a Journal of Cerebral Circulation·Nada El HusseiniLarry B Goldstein
Dec 21, 2018·Stroke; a Journal of Cerebral Circulation·George NtaiosVasileios Papavasileiou
Dec 7, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Lakhmir S ChawlaPaul L Kimmel
Feb 23, 2019·Circulation Journal : Official Journal of the Japanese Circulation Society·Yu-Lun ChengChen-Huan Chen
Mar 20, 2015·Wiener klinische Wochenschrift·Tanja Hojs Fabjan, Radovan Hojs
Apr 24, 2010·European Journal of Heart Failure·George TsagalisKonstantinos Vemmos
Aug 2, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Bharath Chelluboina, Raghu Vemuganti
Oct 3, 2019·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Yu GongYong Gu
Jan 31, 2018·Journal of Intensive Care Medicine·Stefan BüttnerFabian Finkelmeier
Aug 19, 2015·The Neurologist·Fang-Ping YuYong-Yi Yang
Sep 2, 2020·Journal of Nephrology·Giacomo DeferrariEdoardo La Porta
Jun 1, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C R LenihanW C Winkelmayer
Oct 30, 2019·Jornal brasileiro de nefrologia : ʹorgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia·Helbert do Nascimento LimaNorberto Luiz Cabral
May 13, 2020·Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia·Azza Kamal Al ShahawyAmira Hassan El Sharkaway
Nov 23, 2013·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J YangY Zhang
Aug 13, 2015·Aging Clinical and Experimental Research·Han WangJuelin Deng
Jul 9, 2020·Journal of Stroke·Maria H H BalchYousef Hannawi
Jul 15, 2020·Acta neurologica Belgica·Iong Man TungPhyo K Myint
Sep 27, 2020·The European Journal of Neuroscience·Birva ShahPallab Bhattacharya
Dec 6, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Su-Kiat ChuaTaiwan Stroke Registry Investigators
Dec 1, 2020·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Yoshihiro YoshimuraAi Shiraishi

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