PMID: 8175172May 1, 1994

Renal effects of captopril and nitrendipine in transgenic rats with an extra renin gene

Hypertension
C Hirth-DietrichF C Luft

Abstract

We investigated the acute effects of captopril and nitrendipine on renal function and sodium excretion in hypertensive, male, heterozygous transgenic rats harboring a mouse renin gene [TGR (mRen-2)27]. Both drugs reduced blood pressure dose dependently in conscious transgenic rats. The oral ED20 for captopril was 0.5 mg/kg and 2.7 mg/kg for nitrendipine. In orally salt-loaded (20 mL/kg saline) transgenic rats captopril (0.3 to 3.0 mg/kg) reduced sodium excretion by approximately 90% in the 6 hours after administration, whereas equally antihypertensive doses of nitrendipine increased sodium excretion by approximately 100%. The antinatriuretic effect of captopril was accompanied by a reduction in creatinine clearance and a decrease in the excretion of cyclic GMP. In orally water-loaded (20 mL/kg water) transgenic rats captopril also reduced sodium excretion by more than 90%, and nitrendipine slightly increased sodium excretion. In control Sprague-Dawley rats the effects were opposite; namely, captopril tended to increase natriuresis, and nitrendipine caused a small but distinct decrease in sodium excretion. Intravenous captopril in anesthetized transgenic rats caused an antinatriuresis with a decrease in inulin clearance but not ...Continue Reading

References

Jan 17, 1977·Pflügers Archiv : European journal of physiology·P J Harris, J A Young
Feb 1, 1991·Journal of Cardiovascular Pharmacology·J A BijlsmaE J Dorhout Mees
Jan 1, 1987·Journal of Cardiovascular Pharmacology·M SteinhausenN Parekh
Dec 1, 1987·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·A RappelliN Glorioso
Jan 1, 1987·Clinical and Experimental Hypertension. Part A, Theory and Practice·R Di Nicolantonio, T O Morgan
Jul 1, 1987·Acta Physiologica Scandinavica·P Hansell, H R Ulfendahl
Jul 1, 1987·Kidney International·J E HeegD de Zeeuw
Jul 1, 1986·Kidney International·M SteinhausenK R Wilhelm
Nov 1, 1967·The American Journal of Physiology·R L Malvin, A J Vander

Citations

Jan 30, 2002·British Journal of Pharmacology·Johannes-Peter StaschMatthias Schramm
Sep 1, 1996·Clinical and Experimental Pharmacology & Physiology·M Bader, D Ganten
Oct 10, 1997·Journal of Hypertension·K SchneiderF C Luft
Oct 12, 2016·Autonomic Neuroscience : Basic & Clinical·Yimin YaoIvan A Sammut
Mar 1, 1996·Hypertension·M F CallahanM Morris
Aug 22, 2013·Angewandte Chemie·Markus FollmannAlexander Straub
Feb 10, 1999·The American Journal of Physiology·S M JacintoK D Mitchell

Related Concepts

Lopirin
Cyclic GMP
Kidney
Atrial Natriuretic Factor Precursors
Bay e 5009
Potassium
Preprorenin
Sodium
Rats, Holtzman

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