PMID: 8610517Jan 1, 1995Paper

Renal effects of iodixanol in experimental animals

Acta Radiologica. Supplementum
P WaldayE Holtz

Abstract

The effects of the new nonionic dimeric hexa-iodinated contrast media (CM) iodixanol on renal function and morphology were investigated in 7 independent studies in rats, rabbits and monkeys and compared with other iodinated CM. No significant effect on serum creatinine levels was seen at doses up to and including 5 g I/kg in rats and 10.5 g I/kg in rabbits. An immediate and transient increase in proteinuria was found in rabbits when 10.5 g I/kg was administered as a bolus, and when 12.5 g I/kg was administered as a slow infusion in a comparative study with several CM. Increased serum elimination half-life was shown by measuring serum iodine concentrations after the infusion of 12.5 g I/kg. The effect of a high dose of iodixanol on proteinuria and elimination half-life were in this study in the same range as those of the monomeric nonionic CM, but less pronounced than those of the monomeric ionic CM. Reduced renal capacity was induced in male rats by performing unilateral nephrectomy 4 weeks before i.v. injection of iodixanol or iopamidol (2g I/kg). The administration of CM did not affect renal function monitored as serum concentrations of creatinine and urea. The vacuolation of renal proximal tubular cells and kidney iodine ret...Continue Reading

References

Oct 1, 1991·Investigative Radiology·P TervahartialaC G Standertskjöld-Nordenstam
Oct 1, 1989·Kidney International·A S Berns
Apr 1, 1995·Investigative Radiology·G Deray, C Jacobs
Nov 1, 1993·Investigative Radiology·T W Morris
Nov 1, 1993·Investigative Radiology·S GoldfarbM R Rudnick

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Citations

Apr 9, 2010·Investigative Radiology·Gregor JostMartin A Sieber
Jan 1, 1996·European Radiology·J O Karlsson
Jan 3, 2001·American Journal of Physiology. Renal Physiology·K HardiekC Deitrick
Dec 30, 2008·Journal of Biochemical and Molecular Toxicology·XunHui XuJianQiang He

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