PMID: 9446690Apr 4, 1998Paper

Renal effects of neuropeptide Y

Pflügers Archiv : European journal of physiology
A Bischoff, M C Michel

Abstract

Neuropeptide Y (NPY) is a co-transmitter of the sympathetic nervous system including the renal nerves. The kidney expresses NPY receptors, which can also be activated by peptide YY (PYY), a circulating hormone released from gastrointestinal cells. Five subtypes of NPY receptors have been cloned, among which Y1, Y2 and Y5 appear to be involved in the regulation of renal function. NPY produces potent renal vasoconstriction in vitro in isolated interlobar arteries and in the isolated perfused kidney and in vivo upon intrarenal or systemic administration via a Y1 receptor. Nevertheless glomerular filtration rate is altered only little if at all by NPY, indicating a greater effect on the vas efferens than the vas afferens. NPY can inhibit renin release via Y1-like receptors. NPY can stimulate Na+/K+ adenosine triphosphatase (Na+/K+-ATPase) in proximal tubules via Y2 receptors and can antagonize the effects of vasopressin on isolated collecting ducts. It can also act prejunctionally to inhibit noradrenaline release via Y2 receptors. Despite the profound reductions of renal blood flow, systemic NPY infusion can cause diuresis and natriuresis; this is largely independent of pressure natriuresis mechanisms and is possibly mediated by an...Continue Reading

Citations

Mar 8, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·Claudia CzyborraMartin C Michel
Oct 10, 2002·Neuropeptides·R W LambertR D Granstein
Apr 22, 1999·Trends in Pharmacological Sciences·A Bischoff, M C Michel
Feb 28, 2002·Journal of Hepatology·Juan UrizJuan Rodés
Nov 13, 2003·Bioorganic & Medicinal Chemistry Letters·Charles J AndresWeixu Zhai
Apr 20, 2001·British Journal of Pharmacology·A BischoffM C Michel
May 3, 2000·BJU International·B DavisM C Michel
Jul 21, 2005·New Zealand Veterinary Journal·J H MillerA S Coleman
Mar 4, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Miguel Angel Alejandre AlcázarJörg Dötsch
May 24, 2011·Zhurnal evoliutsionnoĭ biokhimii i fiziologii·A D Nozdrachev, P M Masliukov
Mar 6, 2010·Trends in Endocrinology and Metabolism : TEM·Ayse ZenginAmanda Sainsbury
Jan 30, 2007·Diabetic Medicine : a Journal of the British Diabetic Association·P J van GurpC J Tack
Sep 14, 2006·European Journal of Clinical Investigation·P J van GurpC J Tack
Nov 29, 2008·Cell Biochemistry and Function·Janina BriedeGunars Duburs
Dec 21, 2005·Behavioural Brain Research·Thomas WultschPeter Holzer
Jun 5, 2001·Medical Hypotheses·E Sulyok, T Tulassay
Feb 11, 2005·International Journal of Cancer. Journal International Du Cancer·Meike KörnerJean Claude Reubi
Aug 7, 2018·Journal of Developmental Origins of Health and Disease·C JuvetH Chehade
Mar 29, 2000·Canadian Journal of Physiology and Pharmacology·A Bischoff, M C Michel
Jul 4, 2006·The Journal of Pharmacology and Experimental Therapeutics·Cathérine GebhardAlmut Grenz
Apr 16, 2010·Physiological Reviews·Hayo CastropCharlotte Wagner
Jan 13, 2000·The Journal of Pharmacy and Pharmacology·X H ZhaoT Hedner
Feb 28, 2017·Bulletin of Experimental Biology and Medicine·P M MasliukoT L Zefirov
Oct 1, 1998·The American Journal of Physiology·A BischoffM C Michel
Feb 11, 2021·Annual Review of Physiology·John W OsbornLucy Vulchanova
Jun 11, 1999·Journal of the American Society of Nephrology : JASN·V OberhauserL C Rump
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Angela BischoffMartin C Michel

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