Renal endothelial function and blood flow predict the individual susceptibility to adriamycin-induced renal damage

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Peter OchodnickýRichard P E van Dokkum

Abstract

Susceptibility to renal injury varies among individuals. Previously, we found that individual endothelial function of healthy renal arteries in vitro predicted severity of renal damage after 5/6 nephrectomy. Here we hypothesized that individual differences in endothelial function in vitro and renal perfusion in vivo predict the severity of renal damage in a model of adriamycin-induced nephropathy. In three separate studies, the following baseline parameters were measured in healthy male Wistar rats: (1) acetylcholine (ACh)-induced relaxation in small renal arteries in vitro (n = 16) and the contribution of prostaglandins, nitric oxide (NO) and endothelium-dependent hyperpolarizing factor (EDHF) to the relaxation; (2) glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) in spontaneously voiding rats in vivo (n = 16) and (3) the acute effect of the NO-synthase inhibitor N(G)-nitro-l-arginine methyl ester (L-NAME, n = 12) on renal blood flow (RBF) as compared to vehicle infusion (n = 9). Following these measurements, adriamycin (1.75 mg/kg i.v.) was injected and subsequent renal damage after 6 weeks was related to the baseline parameters. Total ACh-induced (r = 0.51, P < 0.05) and EDHF-mediated relaxation (r = 0...Continue Reading

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Citations

Sep 17, 2011·Cardiovascular Research·Magdolna SzántóPéter Bai
Mar 25, 2015·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·A YayM F Sonmez
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Jul 14, 2012·American Journal of Physiology. Renal Physiology·Peter VavrinecRichard P E van Dokkum
Mar 7, 2021·Diagnostics·Pia Clara PafundiFerdinando Carlo Sasso

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