PMID: 9529616Apr 8, 1998Paper

Renal endothelial function in humans

Current Opinion in Nephrology and Hypertension
A Mimran

Abstract

Animal experiments have shown extensively that the endothelial generation of nitric oxide participates in the regulation of renal haemodynamics and function, probably as a factor modulating the effects of endogenous vasoconstrictors. Although the endothelial function of the systemic vasculature is assessed through the vasodilatory effect of acetylcholine, only L-arginine infusion is available for studies of the influence of nitric oxide on the renal circulation in humans. In addition to peripheral vessels, L-arginine is a potent renal vasodilator, having no effect on the glomerular filtration rate; and the renal relaxation induced by L-arginine is markedly blunted in patients with essential hypertension. A few studies showing the renal vasoconstrictor effect of an inhibitor of nitric oxide synthesis have been reported.

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Citations

Aug 4, 2004·Circulation·Francesco PerticoneCarmine Zoccali
Mar 28, 2006·Journal of the American Society of Nephrology : JASN·Carmine ZoccaliFrancesco Perticone
Feb 5, 2002·American Journal of Hypertension·Christian DellesRoland E Schmieder

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