Renal endothelin gene expression is increased in remnant kidney and correlates with disease progression

Kidney International
S OrisioG Remuzzi

Abstract

We previously demonstrated that urinary endothelin excretion is increased in rats with extensive renal mass reduction, a model of progressive renal disease. Here we explored whether the increased urinary endothelin in this model were due to induction of renal pre-pro-endothelin-1 gene and whether changes in endothelin synthetic pathway correlated with the development of glomerulosclerosis. Four groups of rats with renal mass reduction and four groups of sham-operated control rats were studied 7, 30, 60 and 120 days after the surgical procedure. Urinary protein excretion in renal mass ablation animals did not differ from controls at seven days, but was already significantly elevated (P < 0.01) 30 days after surgery. Then proteinuria progressively increased in rats with remnant kidney at values above 400 mg/day at day 120. Serum creatinine concentration also progressively increased with time in renal mass ablation rats, unlike sham-operated animals, and values were significantly different (P < 0.01) at each of the points considered. Rats with renal mass reduction, unlike sham-operated animals, developed focal glomerulosclerosis that affected 8% of glomeruli at day 30, and 24% of glomeruli at day 120. Seven days after renal mass r...Continue Reading

References

Feb 28, 1991·Biochemical and Biophysical Research Communications·T SakuraiT Masaki
Jun 15, 1990·Biochemical and Biophysical Research Communications·H SakamotoF Marumo
Mar 31, 1989·Biochemical and Biophysical Research Communications·H KuriharaY Yazaki
Jun 15, 1989·Biochemical and Biophysical Research Communications·M YoshizumiY Yazaki
Jul 1, 1983·Analytical Biochemistry·A P Feinberg, B Vogelstein

❮ Previous
Next ❯

Citations

Aug 18, 2005·Current Atherosclerosis Reports·Donald G Vidt
Aug 6, 2013·Current Hypertension Reports·Rebecca C MoorhouseNeeraj Dhaun
Sep 12, 2000·Current Hypertension Reports·R R WenzelT Philipp
May 20, 1999·Transplantation Proceedings·D GrekasA Tourkantonis
Aug 5, 1999·Kidney International·H ZhangH Makino
Apr 12, 2000·Kidney International·A Benigni
Nov 13, 1998·The New England Journal of Medicine·G Remuzzi, T Bertani
Feb 9, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Michel Burnier, Valentina Forni
Feb 24, 2001·Current Opinion in Nephrology and Hypertension·A BenigniG Remuzzi
Aug 10, 2000·Transplant International : Official Journal of the European Society for Organ Transplantation·D X DengS Chakrabarti
Oct 22, 2004·Kidney International·Ariela BenigniGiuseppe Remuzzi
Mar 9, 2005·Kidney International. Supplement·Norberto PericoGiuseppe Remuzzi
Mar 27, 2001·Annual Review of Pharmacology and Toxicology·R M Kedzierski, M Yanagisawa
Jul 16, 2004·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Balaram ShresthaMasatoshi Kawana
Oct 30, 1998·Journal of Hypertension·W G Haynes, D J Webb
Sep 8, 2000·Journal of Cardiovascular Pharmacology·J Goddard, D J Webb
Jun 10, 2009·Expert Review of Cardiovascular Therapy·Benjamin J Epstein, Shawn Anderson
Oct 1, 1996·Scandinavian Journal of Clinical and Laboratory Investigation·S J ShinJ H Tsai
Feb 1, 1996·Kidney International·J Egido
Jan 1, 1997·Kidney International·G RemuzziA Benigni
Dec 1, 1996·Kidney International·T J RabelinkH A Koomans
Jul 1, 1997·Kidney International·S AielloG Remuzzi
Dec 6, 2011·Transplantation Reviews·María José SolerJulio Pascual
Dec 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·C ZojaG Remuzzi
Jun 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A TorralboA Barrientos
Apr 9, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·G Remuzzi
Apr 2, 2009·European Journal of Clinical Investigation·L Longaretti, A Benigni
Apr 2, 2009·European Journal of Clinical Investigation·W Neuhofer, D Pittrow
Mar 12, 2004·Nephrology·Chollada BuranakarlKenneth C Bovee
Nov 21, 2009·Journal of Clinical Laboratory Analysis·Ivanka MikulićMonika Zeljko-Tomić
Aug 22, 2006·European Journal of Clinical Investigation·W Neuhofer, D Pittrow

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.