PMID: 8962744Dec 1, 1995Paper

Renal excretion of aluminium in the rat: effect of citrate infusion

Human & Experimental Toxicology
C J LoteM S Freeman

Abstract

When aluminium is administered intravenously to rats, the speciation of the aluminium has a major effect on its renal excretion. Aluminium administered as citrate is much more effectively excreted than that administered as chloride or sulphate. This suggests that citrate could be therapeutically useful in patients who have been exposed to aluminium. Accordingly, we have performed two series of experiments in rats, in which a citrate infusion (intravenous), was begun either immediately after, or one hour after, the administration of an intravenous aluminium sulphate bolus. Both protocols led to markedly enhanced aluminium excretion compared to controls in which only 0.7% NaCl was infused. The enhancement of aluminium excretion was 783% if citrate infusion was begun immediately after aluminium administration, and 335% if the citrate infusion began after an hour delay. The increased excretion was due to an increase in the freely filterable fraction of aluminium. In the control experiments, in which aluminium sulphate administration was followed by 0.7% NaCl infusion, aluminium was found to be deposited in the liver. Administration of citrate one hour after the aluminium bolus did not reduce this liver deposition. The results indic...Continue Reading

References

Jan 1, 1992·Clinical Science·C J LoteH C Saunders
Mar 1, 1995·Human & Experimental Toxicology·N D PriestA J Warner
Jan 1, 1993·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·T H Ittel

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Citations

Aug 29, 1998·Clinical Biochemistry·G F van LandeghemP C D'Haese
Nov 16, 2001·Journal of Inorganic Biochemistry·M SargaziA Shenkin
Nov 10, 2012·Journal of the American Society of Nephrology : JASN·Lauren M BesenhoferKenneth E McMartin
Feb 4, 2005·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Z Rengel
Dec 13, 2006·Toxicology·Chungang Guo, Kenneth E McMartin
Jul 31, 2007·International Journal of Toxicology·Recep KutlubayOmer Levent Tuncay
Oct 12, 2018·Archives of Toxicology·Karin WeisserBrigitte Keller-Stanislawski
Apr 1, 2004·Clinical Science·David G ShirleyChristopher J Lote

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