Renal expression and serum levels of high mobility group box 1 protein in lupus nephritis.

Arthritis Research & Therapy
Agneta ZickertIva Gunnarsson

Abstract

High mobility group box 1 protein (HMGB1) is a nuclear DNA binding protein acting as a pro-inflammatory mediator following extracellular release. HMGB1 has been increasingly recognized as a pathogenic mediator in several inflammatory diseases. Elevated serum levels of HMGB1 have been detected in autoimmune diseases including Systemic lupus erythematosus (SLE). However, the local expression of HMGB1 in active lupus nephritis (LN) is not known. Here we aimed to study both tissue expression and serum levels of HMGB1 in LN patients with active disease and after induction therapy. Thirty-five patients with active LN were included. Renal biopsies were performed at baseline and after standard induction therapy; corticosteroids combined with immunosuppressive drugs. The biopsies were evaluated according to the World Health Organization (WHO) classification and renal disease activity was estimated using the British Isles lupus assessment group (BILAG) index. Serum levels of HMGB1 were analysed by western blot. HMGB1 expression in renal tissue was assessed by immunohistochemistry at baseline and follow-up biopsies in 25 patients. Baseline biopsies showed WHO class III, IV or V and all patients had high renal disease activity (BILAG A/B)....Continue Reading

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Citations

Mar 20, 2012·Arthritis Research & Therapy·David S Pisetsky
Aug 16, 2012·Arthritis Research & Therapy·Deena A AbdulahadMarc Bijl
Dec 29, 2012·Arthritis Research & Therapy·Tianfu Wu, Chandra Mohan
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Methods Mentioned

BETA
biopsy
biopsies
electron microscopy
electrophoresis

Software Mentioned

STATISTICA

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