Renal expression and urinary concentration of EGF and IL-6 in acutely dysfunctioning kidney transplanted patients

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
S Di PaoloF P Schena

Abstract

Despite marked improvements in the success of solid organ transplantation, a significant percentage of transplanted organs is lost due to recurrent episodes of acute cellular rejection. The mechanisms that govern allograft rejection likely include a complex regulatory network of multiple cytokines and growth factors. This study investigated the kidney gene (in situ hybridization) and protein (immunohistochemistry) expression and the urinary excretion rate of IL-6 and EGF in 29 renal transplant recipients: 16 with acute cellular rejection (AR) and 13 with acute tubular damage/cyclosporine toxicity (ATD). AR patients displayed a 4-fold increase of renal IL-6 expression, which localized chiefly to proximal tubular cells and monocytes/macrophages, whereas EGF signal was extremely weak or even absent. In ATD patients, EGF expression was markedly reduced, while IL-6 specific signal was unchanged. In all the patients examined the renal expression of IL-6 and EGF strictly correlated with their urinary excretion rate (r:0.459, P:0.001). Thus, urinary IL-6/EGF ratio was markedly increased in the former group (> 20-fold at day 1), where it paralleled the modifications of plasma creatinine over time (r:0.603, P < 0.0001), and was only slig...Continue Reading

Associated Clinical Trials

Nov 11, 2010·Andre Barreto PereiraAndre Barreto Pereira

Citations

Jun 21, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Suma Bhat HoffmanPatricio E Ray
May 2, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Osun KwonKatherine J Kelly
Jan 12, 2000·Current Opinion in Nephrology and Hypertension·A Chandraker
Dec 24, 2004·Current Opinion in Critical Care·Won K Han, Joseph V Bonventre
Jul 9, 2005·Transplantation·Alfonso M Cueto-ManzanoJosefina Alberú
Oct 25, 2011·Néphrologie & thérapeutique·Nada Alachkar
Jul 1, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·W GongB Sawitzki
Apr 9, 2013·Transplant International : Official Journal of the European Society for Organ Transplantation·Kaoru MurakamiOsamu Ogawa
Dec 29, 1998·Current Opinion in Nephrology and Hypertension·H Rabb
Sep 20, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Young Jun KangPatricia P Jones

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