Renal expression of epidermal growth factor and transforming growth factor-beta1 in children with congenital hydronephrosis

Urology
Yi YangShi Jun Ji

Abstract

To study the potential role of pelviureteral junction obstruction (PUJO) in causing progressive renal damage in children through the renal expression of epidermal growth factor (EGF) and transforming growth factor-beta1 (TGF-beta1). The expression of EGF and TGF-beta1 was evaluated in the renal tissues of 25 children with congenital hydronephrosis by immunohistochemistry, in situ hybridization, and reverse transcriptase polymerase chain reaction techniques. Children with PUJO had a significant increase in TGF-beta1 and a marked reduction in EGF expression compared with controls. The TGF-beta1/glyceraldehyde phosphate dehydrogenase ratio in the hydronephrotic kidney and normal kidney was 0.53 +/- 0.13 and 0.24 +/- 0.10 respectively, and the difference was significant (P = 0.000). The EGF/glyceraldehyde phosphate dehydrogenase ratio in the hydronephrotic kidney and normal kidney was 0.15 +/- 0.06 and 0.55 +/- 0.13, respectively, and the difference was also significant (P = 0.0001). Positive correlations were found between the TGF-beta1 gene and the drainage clearance half-time (r = 0.47; P = 0.018), TGF-beta1 protein and drainage clearance half-time (r = 0.44; P = 0.028), TGF-beta1 gene and histologic grade (r = 0.53; P = 0.006),...Continue Reading

References

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Citations

Jun 21, 2014·Advanced Biomedical Research·Alireza Merrikhi, Emad Bahraminia
Jul 10, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Zhenzhen LiJianguo Wen
Jun 12, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ankur MandeliaAbid Ali
Feb 21, 2007·Expert Opinion on Biological Therapy·Elena Gagliardini, Ariela Benigni
Apr 3, 2009·Kidney International·Robert L ChevalierBarbara A Thornhill
Jan 12, 2011·Journal of Pediatric Urology·Mia Gebauer MadsenTroels Munch Jørgensen
Mar 9, 2011·Nephrology·Jakub ZiegKarel Matousovic
Aug 5, 2010·International Journal of Experimental Pathology·Julie KleinJoost P Schanstra
Oct 10, 2014·International Urology and Nephrology·Xiaoxiang ChenHongqian Guo
Jun 23, 2009·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Cristian SagerErnesto Perazzo
Sep 11, 2014·Molecular & Cellular Proteomics : MCP·Chrystelle LacroixJean-Loup Bascands
Aug 12, 2014·Journal of Biomedical Materials Research. Part a·Rene Olivares-NavarreteBarbara D Boyan
Apr 9, 2016·Human Molecular Genetics·Joanna L ZiffSally J Dawson
Mar 14, 2017·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Laura JacksonRichard J Coward

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