Renal expression of monocyte chemoattractant protein-1 in lupus autoimmune mice.

Journal of the American Society of Nephrology : JASN
C ZojaG Remuzzi

Abstract

Mononuclear cell infiltration in glomeruli and renal interstitium is a prominent feature of some types of glomerulonephritis, including lupus nephritis. The mechanism(s) underlying monocyte influx into the kidney is not fully understood. Recently, monocyte chemoattractant protein-1 (MCP-1) has been identified as a chemotactic factor involved in the recruitment of monocytes/macrophages in the glomeruli of rats with mesangioproliferative as well as anti-glomerular basement membrane glomerulonephritis. In the study presented here, renal MCP-1 mRNA expression in New Zealand Black x New Zealand White (NZB/W) F1 mice, a model of genetically determined immune complex disease that mimics systemic lupus in humans, was investigated. Northern blot analysis revealed a single 0.7 kb MCP-1 transcript of very low intensity in kidneys from 2-month-old NZB/W mice that had not yet developed proteinuria nor renal damage. Message levels, which increased markedly with the progression of nephritis and in association with mononuclear cell infiltration, were 10- and 15- fold higher in 8-10-month-old mice than in 2-month-old mice. By in situ hybridization, increased expression of MCP-1 mRNA was demonstrated in glomeruli and, even more striking, in tubu...Continue Reading

Citations

Jun 9, 1998·Current Opinion in Nephrology and Hypertension·C Lloyd, J C Gutierrez-Ramos
Jan 5, 2000·Journal of the American Society of Nephrology : JASN·Stephan SegererDetlef Schlöndorff
Dec 9, 1998·Kidney International·M Braun, A E Davis
Jun 26, 2001·Journal of the American Society of Nephrology : JASN·Guillermo Pérez DE LemaDetlef Schlöndorff
Feb 15, 2002·Tissue Antigens·F AguilarA Núñez-Roldán
Feb 13, 2001·Annual Review of Medicine·R ZimmermanG Appel
Mar 13, 2003·Kidney International·Hans-Joachim AndersDetlef Schlöndorff
Jun 27, 2003·Human Immunology·Maria Francisca González-EscribanoAntonio Núñez-Roldán
Sep 5, 2003·The Journal of Pharmacology and Experimental Therapeutics·Guillermo Pérez De LemaDetlef Schlöndorff
Dec 16, 2003·Arthritis and Rheumatism·Zahir AmouraGuy Gorochov
Jul 15, 2005·Kidney International·Kevin Sean Eardley, Paul Cockwell
Jul 25, 2021·International Journal of Molecular Sciences·James Greenan-BarrettCoziana Ciurtin
Sep 6, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Rainer BirckFokko J van der Woude
May 23, 2006·Seminars in Immunology·Sandeep KrishnanGeorge C Tsokos
Oct 12, 2007·Kidney International·L Adalid-PeraltaS Koutouzov
Nov 30, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R DonadelliC Zoja
May 23, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Stephen D MarksNeil J Sebire
Mar 6, 2007·Seminars in Nephrology·Volker VielhauerDetlef Schlöndorff
Nov 21, 2008·Autoimmunity·Shinji MorimotoYoshinari Takasaki
Oct 30, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anna-Marie FairhurstChandra Mohan
Aug 5, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Stephen D MarksKjell Tullus
Aug 20, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Min Jeong Kim, Frederick W K Tam

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