Renal expression of organic anion transporters is modified after mercuric chloride exposure: Gender-related differences

Toxicology Letters
María Herminia HazelhoffAdriana Monica Torres

Abstract

Mercuric ions (Hg+2) gain access to proximal tubule cells primarily by the Organic Anion Transporter 1 (Oat1) and 3 (Oat3) in the basolateral plasma membrane. The removal process of Hg+2 ions from cells into the lumen involves an efflux process mainly mediated by the Multidrug Resistance-Associated Protein 2 (Mrp2). The aim of this study was to compare the sex-related differences in the renal expression of Oat1, Oat3, and Mrp2 after mercuric chloride (HgCl2) treatment and analyze their relevance in the mercury-induced nephrotoxicity. Control and Hg-treated male and female Wistar rats were used. Animals received a dose of HgCl2 (4 mg/kg bw, ip) 18 h before the experiments. Tubular injury was assessed by histopathological studies. The renal expression of Oat1, Oat3, and Mrp2 was analyzed by Western Blotting. Mercury levels were determined in urine by cold vapour atomic absorption spectroscopy. HgCl2 treatment increased the expression of renal Oat1 and Mrp2 in both sexes, being more evident in females than in males. The Oat3 renal expression only increased in female rats. The higher expressions of Oat1, Oat3, and Mrp2 could explain the higher renal excretion of mercury and consequently, the lesser renal tubular damage in female ra...Continue Reading

Citations

Jun 5, 2020·Clinical and Experimental Pharmacology & Physiology·Romina V CampagnoAdriana M Torres
Jun 13, 2019·Clinical and Experimental Pharmacology & Physiology·María Julia SeverinAdriana Mónica Torres
Dec 17, 2019·Environmental Science and Pollution Research International·Rafa S AlmeerAhmed E Abdel Moneim
Sep 11, 2020·Human & Experimental Toxicology·M H Hazelhoff, A M Torres
Apr 1, 2021·Renal Failure·Hao-Yang MaYang Du
Mar 20, 2021·Clinical and Experimental Pharmacology & Physiology·Romina V CampagnoAdriana M Torres

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