PMID: 11318824Apr 25, 2001Paper

Renal extraction of insulin and C-peptide in man before and after a glucose meal

Clinical Physiology
Björn Samnegård, T Brundin

Abstract

It was recently shown that the early rise in arterial insulin concentration after an oral glucose meal is largely because of a decreased extraction of the hormone. The kidney is a major site for extraction of insulin and C-peptide. We therefore measured the renal extraction of insulin and C-peptide in eight healthy individuals before and after ingestion of 75 g of glucose. Arterial, renal venous and hepatic venous catheters were inserted. Splanchnic and renal plasma flow were measured, as well as arterial, hepatic venous and renal venous concentrations of insulin and C-peptide. Renal fractional extraction of insulin increased significantly, from 21% to a maximum of 48% after the meal while the renal fractional extraction of C-peptide did not change significantly. Renal blood flow decreased slightly but significantly after the meal. It is concluded that renal fractional extraction of insulin increases and that renal blood flow decreases after a glucose meal.

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Citations

Feb 24, 2010·Proceedings of the National Academy of Sciences of the United States of America·Clara BoucheAllison B Goldfine
Jun 18, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Marcia R BatistaMary Courtney Moore
Oct 29, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Elio F De PaloPaolo Spinella
Aug 27, 2009·Biologics : Targets & Therapy·Lina NordquistBradley T Andresen
Oct 18, 2011·Metabolism: Clinical and Experimental·Michael D JensenRobert A Rizza
Sep 14, 2010·Mathematical Biosciences·J Geoffrey ChaseChristopher E Hann
Aug 2, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jackie A ClowesRichard Eastell
Jan 20, 2018·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Eman A ElbassuoniNashwa F El-Tahawy
Oct 15, 2003·The Journal of Clinical Endocrinology and Metabolism·Jackie A ClowesAubrey Blumsohn

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