Renal failure in sickle cell anemia

Hematology/oncology Clinics of North America
W Y WongD Powars

Abstract

ESRD is a major complication in young adults with sickle cell anemia. As more patients with sickle cell anemia reach the third and fourth decades of life, the incidence of clinically apparent renal insufficiency will increase. As we understand the pathophysiology of renal damage and the effects of various therapies on the sickle renal vasculature, we can tailor specific management without further compromising already impaired renal function. Diagnostic clues must be recognized prior to the onset of irreversible damage, with appropriate intervention initiated at each age group. Bone marrow transplantation (BMT) is the only available cure for SCA at the present time. The demonstration that several distinct haplotypes of the beta s gene cluster on chromosome 11 influence the clinical expression of sickle cell anemia may be useful in delineating children who are at high risk for severe disease, and hence candidates for such hazardous therapeutic interventions as BMT prior to onset of clinically discernable disease. Current BMT preparative regimens can produce renal cortical and pulmonary toxicity, posing a patient selection problem in those cases in which the vasculopathy of the major organs is at an early stage and might be potent...Continue Reading

References

Mar 1, 1990·Archives of Internal Medicine·M Allon
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D K KaulR L Nagel
Oct 19, 1989·The New England Journal of Medicine
Oct 1, 1987·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D J MinerJ E Tomaszewski
Jan 1, 1986·Nephron·J StraussC Abitbol
Jan 1, 1985·Nephron·A TejaniD Sen
Aug 29, 1974·The New England Journal of Medicine·E A FriedmanD M Holden
Sep 1, 1967·Clinica Chimica Acta; International Journal of Clinical Chemistry·L W Statius van EpsA M Struyker Boudier
Jun 27, 1981·British Medical Journal·T Sherwood
Mar 1, 1982·Medicine·G EknoyanJ C Ayus
Oct 1, 1980·Clinical Science·P E de JongL W Statius van Eps
Nov 23, 1995·The New England Journal of Medicine·U S Barzel
Feb 11, 1995·BMJ : British Medical Journal·N A HamdyI T Fairey
May 22, 1995·Archives of Internal Medicine·D D MakiB L Kasiske
Nov 1, 1994·Kidney International·M E De Paepe, M Trudel
Feb 1, 1993·Kidney International·D J SherrardG V Segre

❮ Previous
Next ❯

Citations

Dec 1, 2007·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·A V ShrikhandeA K Agrawal
Jun 24, 2003·Blood Reviews·Christiane Vermylen
Jun 19, 2002·European Journal of Haematology·Iheanyi OkpalaIan Abbs
Sep 10, 2002·Journal of Pediatric Hematology/oncology·Patricia Geraty McBurneyKathleen Mood McKie
Jul 25, 2012·Hematology Reports·Sanjeev Shyam RaoVijay B Shah
Jun 24, 2011·Kidney International·Oluwatoyin F Bamgbola
Mar 8, 2016·Néphrologie & thérapeutique·Philippe RémyFrédéric Galactéros
May 21, 2014·American Journal of Hematology·Kenneth I AtagaDavid R Archer
May 18, 2011·Annals of Tropical Paediatrics·M MawandaC Ndugwa
Apr 12, 2001·European Journal of Anaesthesiology·T FrietschK F Waschke
Mar 8, 2000·American Journal of Hematology·K I Ataga, E P Orringer
Jan 16, 1999·Journal of the American Society of Nephrology : JASN·P Saborio, J I Scheinman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia Cerebrovascular Disease

Basal ganglia cerebrovascular disease is a condition where the blood vessels in the basal ganglia are damaged or malfunction. Discover the latest research on basal ganglia cerebrovascular disease here.

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Related Papers

Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion
A V ShrikhandeA K Agrawal
Anesthesiology Clinics of North America
Marie Csete
© 2021 Meta ULC. All rights reserved