Renal function after cardiopulmonary bypass surgery in patients with impaired renal function. A randomized study of the effect of nifedipine

European Journal of Anaesthesiology
B J WitczakJ F Bugge

Abstract

Postoperative acute renal failure predicts morbidity and mortality. We investigated the effect of nifedipine infusion on glomerular filtration rate in patients with impaired renal function undergoing cardiopulmonary bypass surgery. Twenty patients accepted for coronary bypass and/or heart valve surgery were enrolled prospectively and randomized to nifedipine infusion or no treatment. Males and females with creatinine 150 micromol L(-1) and 130 micromol L(-1), respectively, were included. Patients with unstable angina pectoris, ejection fraction 35% and those on dialysis were excluded. Glomerular filtration rate was measured preoperatively and 48 h postoperatively. Creatinine clearance was measured preoperatively and 0-4, 20-24 and 44-48 h postoperatively. There were no statistically significant differences in patient characteristics. Biochemical markers in plasma and urine were measured before and 48 h after surgery. The mean +/- SD preoperative glomerular filtration rates were 32.2 +/- 11.5 and 31.4 +/- 17.0 mL min-1 per 1.73 m2 in the nifedipine and control groups (P = 0.90), respectively. There was no statistically significant change in the glomerular filtration rate or in creatinine clearance over time within or between gro...Continue Reading

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Citations

Aug 20, 2008·British Journal of Anaesthesia·G LemaR Canessa
Mar 30, 2010·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Terje VeelHilde Pleym
Feb 25, 2009·European Journal of Anaesthesiology·Guillermo LemaRoberto Jalil
Nov 18, 2009·British Journal of Clinical Pharmacology·Michael A BarrasBruce Green
Sep 13, 2013·The Cochrane Database of Systematic Reviews·Mathew ZachariasNiamh P Conlon

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