Renal Function and exposure to Bisphenol A and phthalates in children with Chronic Kidney Disease

Environmental Research
Julia MalitsLeonardo Trasande

Abstract

Exposure to Bisphenol A (BPA) and phthalates is ubiquitous among adults and children in the United States. Among children and adolescents, those with chronic kidney disease (CKD) are potentially at greater risk of adverse effects from BPA and phthalate exposure. The objective of this study was to evaluate BPA and phthalate exposure among children with CKD and evaluate associations with three measures of kidney function. Cross sectional study. The CKD population was represented by the Chronic Kidney Disease in Children (CKiD) Study, a multicenter, prospective cohort study of children with impaired kidney function in the US. The main outcome was assessment of the relationship between chemical exposures and clinical laboratory findings at enrollment into CKiD. Data collected at baseline from participants 1 to 17 years old (N = 538) were analyzed. Urinary BPA and phthalate levels were evaluated at this time point. Data from the National Health and Nutrition Examination Survey (NHANES), a nationally representative pediatric population, were used for comparison to the CKiD cohort. Urinary BPA and phthalate levels in the CKiD population were consistently lower than levels detected in healthy children. Additionally, BPA was not signifi...Continue Reading

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Citations

Jan 23, 2020·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Ruolin LiAijun Chen
Oct 20, 2020·Frontiers in Public Health·Manoj KumarRajnarayan Tiwari
Jul 13, 2019·Environmental Research·Ya MaHuizhen Zhang
Jan 15, 2020·Computational and Structural Biotechnology Journal·Jing ZhaoJing Jiang
May 6, 2021·Environment International·Melanie H JacobsonLeonardo Trasande
May 10, 2021·The Science of the Total Environment·Wei-Hsiang ChangHsiu-Ling Chen
May 21, 2021·Journal of Feline Medicine and Surgery·Petr MaršálekVladimír Večerek
Aug 7, 2021·Biomolecules·Rafael Moreno-Gómez-ToledanoRicardo J Bosch
Sep 24, 2021·Annual Review of Pharmacology and Toxicology·Akhgar GhassabianLeonardo Trasande

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