PMID: 6109432Jan 1, 1980Paper

Renal function and morphology in long-term lithium and combined lithium-neuroleptic treatment

Acta Medica Scandinavica
G BuchtB Winblad

Abstract

Ten patients on long-term lithium therapy and ten on lithium and neuroleptics (combination therapy) were examined with renal biopsy and tests of renal function. Patients on combination therapy had more pronounced histopathological changes and lower concentrating capacity than patients on lithium alone. Patients on combination therapy had received a larger total dose of lithium and had had higher maximum serum lithium levels than patients on lithium alone. Patients with large daily urine volumes had a low concentrating capacity. There was a negative correlation between degree of histopathological lesions and urinary concentrating capacity. Estimation of urinary concentrating capacity seems to be of value for the assessment of renal lesions in lithium treatment.

References

Apr 8, 1978·Lancet·G Bucht, A Wahlin
Jun 17, 1978·Lancet·G D BurrowsP Kincaid-Smith
Sep 1, 1977·Kidney International·J HestbechS Olsen

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Citations

Aug 13, 1981·The New England Journal of Medicine·A Wahlin, G Bucht
Jan 1, 1982·Annals of the New York Academy of Sciences·M J Kreek, N Hartman
Dec 4, 2003·Journal of Clinical Pharmacy and Therapeutics·S Dashti-KhavidakiF Fahimi
Sep 1, 1981·Acta Pharmacologica Et Toxicologica·S ChristensenP Faarup
Mar 1, 1982·British Journal of Clinical Pharmacology·L F Prescott
Jul 30, 2014·Bipolar Disorders·James Conor KinahanBrendan D Kelly
Mar 1, 1988·Acta Psychiatrica Scandinavica·M J GarveyR Adelman
Nov 1, 1983·Acta Psychiatrica Scandinavica·H Bendz
Jan 1, 1993·International Journal of Psychiatry in Medicine·W A MortonR B Lydiard
Oct 19, 2007·Kidney International·M P AlexanderA K Singh

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