Renal function and oncologic outcomes in nephron sparing surgery for renal masses in solitary kidneys.

World Journal of Urology
Daniel J LeeJames M McKiernan

Abstract

With low life expectancy rates in hemodialysis patients, the preservation of renal parenchyma must be weighed against the oncological outcomes in considering partial nephrectomy (PN) in solitary kidneys. The main objective of this study was to assess the oncologic and functional outcomes after PN in patients with solitary kidneys. A retrospective analysis of the Columbia University Medical Center Urologic Oncology database found 38 patients who underwent PN in the setting of a solitary kidney from 1988-2008. Chronic kidney disease (CKD) was defined as GFR of <60 cc/min/1.73 m(2). Kaplan-Meier analysis was used to estimate overall survival, cancer-specific survival, and local recurrence-free survival. The study group was followed for a median of 29 months, with a mean age of 63.2 years (range 35-83). Only one patient required postoperative long-term hemodialysis. Two out of 38 patients had a Clavien III postoperative complication. Twenty-one (55.3%) of the patients had preoperative CKD, while 29 (76%) patients had CKD postoperatively. Those who had CKD at the most recent follow-up had significantly larger tumors removed (P < 0.05). Of the 32 patients with renal cell carcinoma (RCC), 6 (18.8%) had a local recurrence at a median 3...Continue Reading

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Citations

Mar 19, 2013·The Journal of Urology·Christina B ChingAmr F Fergany
Jan 20, 2016·Clinical Genitourinary Cancer·Csaba BercziTibor Flasko
Dec 6, 2011·European Urology·Martin MarszalekHendrik Van Poppel
May 15, 2015·World Journal of Urology·Tarek P GhoneimPaul Russo
Jun 6, 2016·International Journal of Surgery·Nicholas RaisonBen Challacombe
Jun 13, 2014·Current Opinion in Urology·Homayoun ZargarJihad H Kaouk
Aug 4, 2012·Scottish Medical Journal·L BarryP Rajan
May 8, 2014·Urologia·Nazario FoschiPierfrancesco Bassi
Apr 11, 2018·Scientific Reports·Ryan K OroscoQuyen T Nguyen
Mar 5, 2016·Journal of Surgical Oncology·Mehrdad AlemozaffarViraj A Master
Sep 5, 2021·World Journal of Urology·Michael StaehlerB Schlenker

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