Renal function and peak exercise oxygen consumption in chronic heart failure with reduced left ventricular ejection fraction

Circulation Journal : Official Journal of the Japanese Circulation Society
Domenico ScrutinioMetabolic Exercise test data combined with Cardiac and Kidney Indexes (MECKI) Score Research Group

Abstract

Chronic kidney disease is associated with sympathetic activation and muscle abnormalities, which may contribute to decreased exercise capacity. We investigated the correlation of renal function with peak exercise oxygen consumption (V̇O2) in heart failure (HF) patients. METHODS AND RESULTS: We recruited 2,938 systolic HF patients who underwent clinical, laboratory, echocardiographic and cardiopulmonary exercise testing. The patients were stratified according to estimated glomerular filtration rate (eGFR). Mean follow-up was 3.7 years. The primary outcome was a composite of cardiovascular death and urgent heart transplantation at 3 years. On multivariable regression, eGFR was predictor of peakV̇O2(P<0.0001). Other predictors were age, sex, body mass index, HF etiology, NYHA class, atrial fibrillation, resting heart rate, B-type natriuretic peptide, hemoglobin, and treatment. After adjusting for significant covariates, the hazard ratio for primary outcome associated with peakV̇O2<12 ml·kg(-1)·min(-1)was 1.75 (95% confidence interval (CI): 1.06-2.91; P=0.0292) in patients with eGFR ≥60, 1.77 (0.87-3.61; P=0.1141) in those with eGFR of 45-59, and 2.72 (1.01-7.37; P=0.0489) in those with eGFR <45 ml·min(-1)·1.73 m(-2). The area unde...Continue Reading

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Citations

Apr 27, 2017·Annals of the American Thoracic Society·Piergiuseppe AgostoniMichele Emdin
Mar 8, 2018·Heart Failure Reviews·Michele CorrealeUNKNOWN Master Program Students on Drug Development for Heart Failure
Dec 14, 2017·ESC Heart Failure·Gaia CattadoriClaudio Anzà
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Nov 30, 2019·European Journal of Heart Failure·Sara RovaiUNKNOWN MECKI Score Research Group (see Appendix 1)
Nov 9, 2019·Heart and Vessels·Yoshimi SatoSatoaki Matoba
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Nov 27, 2020·European Journal of Preventive Cardiology·Andrea TedeschiMassimo F Piepoli
Nov 27, 2020·European Journal of Preventive Cardiology·Gaia CattadoriMichele Correale
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Mar 28, 2021·ESC Heart Failure·Javier Roibal PravioMaria Generosa Crespo Leiro
Apr 7, 2021·Geriatrics & Gerontology International·Shinjiro MiyazakiTetsuo Minamino
May 31, 2020·The American Journal of Cardiology·Bishnu P DhakalChantal A ElAmm

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