Renal function at the time of renal biopsy as a predictor of prognosis in patients with primary AL-type amyloidosis

Clinical and Experimental Nephrology
Yutaka OsawaF Gejyo

Abstract

Amyloid light-chain (AL)-type amyloidosis is a plasma cell disorder with a poor prognosis for survival. Although prognostic factors, such as the number of organs involved and heart function or failure in respond to therapy have been clarified based on studies including a large series of patients, there are large interindividual differences in the prognosis of patients with primary AL-type renal amyloidosis. To clarify the prognostic factors of AL-type renal amyloidosis, we retrospectively investigated the clinical manifestations, histopathological data, and prognosis of 21 patients with amyloidosis, who had been diagnosed by renal biopsy. Eleven patients died, at a mean observational time of 21.7 months after renal biopsy, whereas the mean observational time was 51.0 months for the 10 patients who survived. The creatinine clearance rate was significantly higher, and the serum creatinine concentration and the grade of interstitial damage were significantly lower in surviving patients (P < 0.05). The presence of amyloid fibrils in organs other than the kidney did not influence prognosis for survival. However, the intraventricular septum was thinner in surviving patients (P < 0.1). Thirteen patients had undergone melphalan-prednis...Continue Reading

Citations

Oct 6, 2010·Heart and Vessels·Mitsuyo ItabashiKosaku Nitta
Jan 5, 2008·Clinical and Experimental Nephrology·Shinichi NishiFumitake Gejyo
Feb 12, 2011·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Eric T StooplerEdward A Stadtmauer
Nov 28, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ying YaoWan-Zhong Zou
Jun 15, 2017·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Takeshi KurodaIchiei Narita
May 20, 2020·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·E O FonsecaJ R Almeida
Feb 13, 2015·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Chang-Qing LuoYu-Mei Wang
Mar 30, 2021·Clinical Kidney Journal·Joris J HoelbeekSandrine Florquin

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