Renal function changes and NHS resource use in breast cancer patients with metastatic bone disease treated with IV zoledronic acid or oral ibandronic acid: a four-centre non-interventional study

Journal of Medical Economics
S HoustonE Hamilton

Abstract

To describe renal function monitoring practice in patients with metastatic bone disease (MBD) treated with IV zoledronic acid (ZA) and oral ibandronic acid (IA), the management pathways and NHS hospital resources used. Medical records of 189 patients; IA (91), ZA (98) with primary breast cancer and MBD were reviewed, and data collected on renal monitoring and hospital visits during bisphosphonate therapy. Time and motion review of resources to administer the bisphosphonates was also conducted. Only 30% of patients given ZA and no patient given IA had baseline creatinine clearance (CrCl) recorded. Calculated baseline CrCl suggested impaired renal function in 33% ZA and 29% IA patients. Dose reductions were not made correctly in 29 ZA and 2 IA patients whose monitoring suggested it. ZA patients made more clinic and day care attendances than IA-treated patients, at twice the cost. Staff activity and patient time per visit was higher with ZA than IA. Although limited by retrospective design, these results demonstrate that in many patients, CrCl is not calculated before or during treatment with bisphosphonates. Renal function deteriorated in many patients during therapy. In view of these effects, practice should be reviewed to ensur...Continue Reading

References

Feb 24, 2001·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·P E Kintzel
Jun 6, 2002·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·A CorsoM Lazzarino
Sep 5, 2003·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J-J BodyUNKNOWN MF 4265 Study Group
Sep 26, 2003·The New England Journal of Medicine·Bernard S Chang, Daniel H Lowenstein
Oct 19, 2004·Seminars in Oncology·David Cameron
Jun 16, 2005·The Annals of Pharmacotherapy·Aline MunierZiad Massy
Nov 3, 2005·The Oncologist·Jean-Jacques BodyFrieder Bauss
Mar 21, 2006·Annals of Oncology : Official Journal of the European Society for Medical Oncology·T Tanvetyanon, P J Stiff
Sep 15, 2006·The Oncologist·David CameronIngo Diel
Dec 14, 2006·Clinical Drug Investigation·Sue-Anne McLachlanBengt Bergström
Dec 14, 2006·Clinical Drug Investigation·Martin PecherstorferBengt Bergström
Oct 2, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M AaproB Thürlimann
Nov 14, 2008·Expert Opinion on Pharmacotherapy·Martin Pecherstorfer

❮ Previous
Next ❯

Citations

Apr 13, 2012·Cancer Treatment Reviews·Vito LongoFranco Silvestris
Dec 17, 2014·Revue des maladies respiratoires·A-C ToffartL Sakhri

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.