PMID: 8462386Apr 1, 1993Paper

Renal function changes in microalbuminuric normotensive type II diabetic patients treated with angiotensin-converting enzyme inhibitors

Diabetes Care
R RomeroA Sanmarti

Abstract

To determine the effects of captopril on microalbuminuria and renal function in normotensive type II diabetic patients. A total of 26 patients were randomized in two homogeneous groups for clinical and analytical data in a 6-mo follow-up study. Group A received captopril (initial dose: 12.5 mg daily, increased according to tolerance); group B was untreated. Microalbuminuria decreased only in the treated group at 6 mo (P = 0.044) and a significant (P = 0.027) mean percentage change on microalbuminuria excretion between the groups was observed. Filtration fraction decreased in group A (baseline: 0.23 +/- 0.03; 6 mo: 0.22 +/- 0.04) and increased in group B (baseline: 0.22 +/- 0.04; 6 mo: 0.25 +/- 0.04) with a significant mean percentage change between the groups at 6 mo (P = 0.032). The mean percentage change in microalbuminuria was significantly correlated with a mean percentage change in diastolic blood pressure throughout the trial. Neither metabolic control nor sodium or protein intake changed in either group during the trial. These results suggest that captopril can help arrest microalbuminuria in normotensive type II diabetic patients, with a decrease in diastolic blood pressure and filtration fraction after a 6-mo treatment.

Citations

Jan 1, 1995·Journal of Diabetes and Its Complications·C E Mogensen
Mar 5, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ausilia MaioneGiovanni F M Strippoli
Sep 1, 1994·British Heart Journal·C E Mogensen
Jul 30, 2003·Pharmacotherapy·Robert A HamiltonJason Demers
Nov 24, 2005·Prostaglandins & Other Lipid Mediators·L DazaJ Flores
May 1, 1996·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·J E Murray
May 1, 1996·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·F O Karlsson, A J Garber
Aug 1, 1994·Diabetic Medicine : a Journal of the British Diabetic Association·R E GilbertG Jerums
Mar 1, 1996·Journal of Cardiovascular Pharmacology·L M MolyneauxD K Yue
Sep 15, 1998·Journal of Cardiovascular Pharmacology·H J Bilo, R O Gans
Aug 1, 1997·Scottish Medical Journal·K McKenna, C Thompson
Feb 28, 2021·Kidney International·UNKNOWN Kidney Disease: Improving Global Outcomes (KDIGO) Blood Pressure Work Group
Oct 2, 2020·Kidney International·UNKNOWN Kidney Disease: Improving Global Outcomes (KDIGO) Diabetes Work Group

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