PMID: 4003100Apr 1, 1985

Renal function in 153 manic-depressive patients treated with lithium for more than five years

Acta Psychiatrica Scandinavica
H LøkkegaardK Rasmussen


Renal function was examined in 153 manic-depressive patients treated with lithium for more than 5 years, mean 10 years. No significant change was detectable in plasma creatinine. Glomerular filtration rate (GFR) decreased slightly, but significantly, and not until after 17 years of treatment did the regression line reach the lower confidence limit in the reference material. GFR was generally only moderately decreased. Renal concentrating capacity was significantly reduced during the whole investigation period and did not change with time. GFR was independent of the dosage pattern. The diuresis did not differ markedly in patients given one or three daily doses. In a two-dose group predominantly treated with slow-release tablets, the diuresis was somewhat higher in 75% of the patients but much higher for the rest of the group. Since the prophylactic effect of lithium was the same in the one-dose group (mean dosage 21 mmol/day) as in the two-dose and three-dose groups (mean dosage 27-28 mmol/day), our data indicate that generally employed lithium doses may be reduced somewhat without loss of prophylactic efficacy.


Sep 29, 1979·Lancet·P Kincaid-SmithR G Walker
Jun 2, 1979·British Medical Journal·R P HullinD B Morgan
Nov 1, 1979·Acta Psychiatrica Scandinavica·P VestergaardM Schou
Jan 1, 1977·Scandinavian Journal of Urology and Nephrology·J Bröchner-MortensenP Rodbro
Apr 1, 1977·Annals of Internal Medicine·B S ShaikhF J Miller
Sep 1, 1977·Kidney International·J HestbechS Olsen
Nov 1, 1972·Scandinavian Journal of Clinical and Laboratory Investigation·J Bröchner-Mortensen
Aug 1, 1982·Acta Psychiatrica Scandinavica·P PlengeO J Rafaelsen
Oct 1, 1980·Acta Psychiatrica Scandinavica·A CoppenR G Price
Apr 1, 1981·Acta Psychiatrica Scandinavica·P Vestergaard, A Amdisen
Jul 1, 1980·The American Journal of Psychiatry·R H GernerM A Kirschenbaum
Nov 1, 1980·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·P GrofJ Kenny
Mar 1, 1981·The American Journal of Psychiatry·J R DepauloD G Sapir
Jun 30, 1960·The New England Journal of Medicine·R D LINDEMANL G RAISZ
May 1, 1972·Postgraduate Medical Journal·A S DontasP Papanayiotou


Jun 15, 1995·Clinica Chimica Acta; International Journal of Clinical Chemistry·M WernerR Nayar
Jan 1, 1988·Journal of Psychiatric Research·M Schou
Jan 1, 1995·Life Sciences·M A VitalJ Palermo-Neto
Mar 1, 1989·Toxicology Letters·G A Porter
May 10, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Tayfun TuranFahrettin Keleştimur
Nov 1, 1989·Psychological Medicine·D G Waller, J G Edwards
Jan 1, 1994·Acta Psychiatrica Scandinavica·R F Kehoe
Nov 1, 1987·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R BotonD Batlle
Jul 30, 2014·Bipolar Disorders·James Conor KinahanBrendan D Kelly
Jul 1, 1986·Comprehensive Psychiatry·P Plenge, E T Mellerup
Apr 28, 2009·Journal of Psychopharmacology·R PaulC Kelly
Apr 3, 2012·Journal of Geriatric Psychiatry and Neurology·Soham RejKenneth Shulman
Mar 1, 1988·Acta Psychiatrica Scandinavica·M J GarveyR Adelman
May 1, 1989·Acta Psychiatrica Scandinavica·G ConteE Sacchetti
May 1, 1986·Acta Psychiatrica Scandinavica·O HetmarO J Rafaelsen
Apr 11, 2019·Irish Journal of Psychological Medicine·James Conor KinahanBrendan D Kelly
May 15, 2009·Journal of Clinical Psychopharmacology·David S JanowskyJohn M Davis
Oct 25, 2011·Journal of Clinical Psychopharmacology·David S JanowskyJohn M Davis
Jul 10, 2014·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Soham RejKarl Looper
Sep 1, 1987·The Australian and New Zealand Journal of Psychiatry·G F Johnson
Jan 1, 1988·Acta Psychiatrica Scandinavica. Supplementum·P Plenge, E T Mellerup
Jun 16, 2015·Journal of Clinical Psychopharmacology·James Conor KinahanBrendan D Kelly
Jan 1, 1991·The British Journal of Psychiatry : the Journal of Mental Science·O HetmarT G Bolwig
Mar 20, 1989·The Medical Journal of Australia·C R George

Related Concepts

Manic Disorder
Dose-Response Relationship, Drug
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