PMID: 8979741Jun 1, 1996Paper

Renal function in endurance trained volunteers during prolonged restriction of muscular activity

Panminerva Medica
Y G ZorbasA Naexu

Abstract

It has been demonstrated that changes in the functional status of the kidneys are basically responsible for the impaired fluid-electrolyte metabolism in physically healthy volunteers during hypokinesia (decreased number of walking steps/day). Thus, the objective of this investigation was to determine the functional changes of the kidneys of 20 endurance trained male volunteers aged 23 to 26 years with an average maximum oxygen uptake 65 ml.kg-1.min-1 during 364 days of hypokinesia (HK). All volunteers were on 14.6 km/day (10,000 running steps/day) prior to their exposure to HK. All volunteers were randomly assigned to one of the two groups: Ten volunteers were placed continuously under 14.6 km/day (10,000 running steps/day) (control subjects) and ten to 2.9 km/day (3,000 walking steps/day) (hypokinetic subjects). During the prehypokinetic period of 60 days and during the hypokinetic period of 364 days urinary and plasma electrolytes, glomerular filtration rate (GFR), renal plasma flow (RPF), were determined and isotope renographic tests were performed. The hypokinetic volunteers displayed a significant increase in urinary and plasma concentrations of electrolytes, a significant decrease in glomerular filtration rate and renal p...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.