Renal function in juvenile rats subjected to prenatal malnutrition and chronic salt overload

Experimental Physiology
João Carlos G MagalhãesAna D O Paixão

Abstract

Dietary sodium may contribute to hypertension and to cardiovascular and renal disease if a primary deficiency of the kidney to excrete sodium exists. In order to investigate whether chronic 1% NaCl in the drinking water changes blood pressure and renal haemodynamics in juvenile Wistar rats subjected to prenatal malnutrition, an evaluation of plasma volume, oxidative stress in the kidney, proteinuria and renal haemodynamics was carried out. Malnutrition was induced by a multideficient diet. Mean arterial pressure, renal blood flow and glomerular filtration rate (GFR) were measured using a blood pressure transducer, a flow probe and inulin clearance, respectively. Plasma volume and oxidative stress were measured by means of the Evans Blue method and by monitoring thiobarbituric acid reactive substances (TBARS) in the kidneys, respectively. Urinary protein was measured by precipitation with 3% sulphosalicylic acid. It was observed that prenatally malnourished rats presented higher values of plasma volume (26%, P < 0.05), kidney TBARS (43%, P < 0.01) and blood pressure (10%, P < 0.01) when compared with the control group. However, they showed no change in renal haemodynamics or proteinuria. Neither prenatally malnourished nor contr...Continue Reading

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Citations

Jul 16, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Henriqueta D CardosoAna D O Paixão
May 25, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Leucio D Vieira-FilhoAna D O Paixão
Mar 1, 2008·Clinical and Experimental Pharmacology & Physiology·Caroline RugaleBernard Jover
May 29, 2009·Clinical and Experimental Pharmacology & Physiology·Leucio D Vieira-FilhoAdalberto Vieyra
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Nov 15, 2013·Biology of Reproduction·Ana D Paixão, Barbara T Alexander
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Feb 1, 2013·American Journal of Physiology. Renal Physiology·Martha FrancoBernardo Rodriguez-Iturbe
Sep 28, 2021·Toxicon : Official Journal of the International Society on Toxinology·Regina Souza AiresLeucio Duarte Vieira

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