Renal function in male Sprague-Dawley rats concurrently exposed to long-term nicotine (3-{1-methyl-2-pyrrolidinyl}pyridine) and methylated spirits (methyl alcohol)

Renal Failure
R G Cooper

Abstract

Abuse of nicotine and methylated spirits is a global problem. The current study determined the concurrent influence of nicotine and methylated spirits on renal hemodynamics. Two series of experimental protocols were designed: conscious and anesthetized vehicle loading. Conscious animals received nicotine (0.1 mg x kg(-1) bwt, 0.26-0.30 mL), methylated spirits (1.0 g x kg (-1) bwt, 0.26-0.30 mL), combined nicotine and methylated spirits, and control animals (water, 0.26-0.30 mL). Anesthetized animals were challenged with a continuous jugular infusion of 0.077M NaCl. Plasma nicotine concentration was significantly elevated in combined conscious treatments by comparison with animals infused nicotine alone. Plasma arginine vasopressin was significantly attenuated in combined conscious groups, and those infused methylated spirits alone. Aldosterone was elevated in all conscious groups. Both plasma ethanol and methanol concentrations were elevated in rats concurrently administered nicotine and methylated spirits compared with those given methylated spirits alone. Urinary Na(+) levels were significantly elevated in all anesthetized groups associated with attenuated aldosterone concentrations. Plasma nicotine concentrations were increa...Continue Reading

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Citations

Apr 23, 2011·American Journal of Physiology. Renal Physiology·Istvan AranyLuis A Juncos
Jan 28, 2014·PloS One·Iqra IshtiaqueAfra Ishtiaque

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