PMID: 16529164Mar 15, 2006Paper

Renal function in subjects with minimal change steroid-responsive nephrotic syndrome in childhood

Annales Academiae Medicae Stetinensis
Aniela Strzelecka-Lichota

Abstract

Steroid-responsive idiopathic nephrotic syndrome (SRlNS) with minimal change disease (MCD) is the most common cause of nephrosis in childhood. MCD is no longer considered to be easily curable and the finding of minimal changes is no guarantee that the disease will not progress to renal failure or to another form of glomerulonephritis. In the present work, renal function was studied in subjects presenting with SRINS and MCD in childhood. Attention focused on glomerular filtration, integrity of the filtration membrane, reabsorption in the proximal tubule, and renal vessels. The influence of age, age at onset, recurrences, duration of the active phase, duration of remission, 24-hour protein loss and Up/UCr ratio on renal function was analyzed. An attempt was made to establish if patients with lasting remission require periodic follow-up by a nephrologist. The study group consisted of 31 subjects with SRINS in childhood. Remission of at least one year was ascertained at the time of study. A hyperfiltration subgroup (n=11) with creatinine clearance (Ccr) of > 150 mL/min/1.73 m2 was formed. The control group included twelve healthy volunteers matched for age and gender. Creatinine and lithium clearance, fractional lithium secretion, ...Continue Reading

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