Renal Function Profiles in Preterm Neonates With Birth Asphyxia Within the First 24 H of Life

Frontiers in Pediatrics
Yu Zhang, Hui-Hui Zeng

Abstract

The characteristics of early renal function in preterm neonates of different gestational ages (GAs) with birth asphyxia (BA) remain unclear. Kidneys are sensitive to oxygen deprivation, and renal insufficiency may occur within 24 h of BA. We aimed to elucidate the renal function profiles within the first 24 h after the development of BA among vulnerable preterm neonates of different GAs. The medical records of 128 preterm neonates born to mothers with normal renal function were retrospectively analyzed. Data regarding the serum creatinine (SCr) and urea nitrogen (BUN) levels in venous blood, estimated creatinine clearance (eCCI) within the first hours after birth, and urinary output (UOP) in the first 24 h after birth were compared between the preterm with BA population and GA-matched population without BA (n = 64 and n = 64, respectively). Significantly higher SCr levels and lower eCCI were observed in mid-late preterm neonates with BA than in preterm neonates without BA (84.05 versus [vs.] 64.20 μmol/L, z = 4.41, p < 0.001; 15.02 vs. 21.30 mL/min/1.73 m2, z = 3.57, p < 0.001, respectively). Very preterm neonates showed a higher UOP (2.01 vs. 1.66 mL/kg/h, z = 2.01, p = 0.045) after the development of BA than before. In preter...Continue Reading

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Methods Mentioned

BETA
serum collection
pharmacotherapy

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SPSS

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