PMID: 6166267Feb 1, 1981Paper

Renal function studies in an experimental model of papillary necrosis in the rat

Archives internationales de physiologie et de biochimie
R VanholderS Ringoir

Abstract

Twenty four hours after i.v. injection of bromoethylamine-hydrobromide (BEA) in rats, a uniform papillary necrosis is observed. The present study investigates the renal functional and the papillary haemodynamics in response to acute volume expansion (12% of body weight) in this model. Renal function studies were performed in hydropenic and volume expanded sham- or BEA-injected rats. In hydropenic normal animals a GFR of 1.97 +/- 0.14 ml/min, an urinary osmolarity (UOsm) of 1 011 +/- 94.5 mOsm/kg and a fractional sodium excretion (FENa) of 0.18 +/- 0.026% were obtained. In contrast, BEA-treated hydropenic animals showed a lower GFR (1.16 +/- 0.14 ml/min), UOsm (469 +/- 30.31 mOsm/kg) and a higher FENa (0.37 +/- 0.06%). In volume expansion a similar UOsm and FENa were obtained in both groups. The papillary plasma flow (PPF) was measured in each of the experimental groups by the albumin accumulation technique. The mean value in hydropenic normal animals was 50.65 +/- 2.12 m 100 g-1 min-1 and increased to 66.02 +/- 2.00 ml 100 g-1 min-1 after volume expansion (P less than 0.001). In BEA rats the PPF was 58.86 +/- 2.33 ml 100 g-1 min-1 in hydropenia (P less than 0.01 vs. control animals) and remained unchanged after volume expansion...Continue Reading

References

Jan 1, 1977·Annual Review of Physiology·N H LameireJ H Stein
Mar 1, 1979·Kidney International·J A ArrudaR Baranowski
Mar 1, 1978·The Journal of Clinical Investigation·E L ChuangJ H Stein
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Oct 1, 1964·The Journal of Clinical Investigation·L E EARLY, R M FRIEDLER

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Citations

Feb 1, 1997·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·E HolmesJ K Nicholson
Jun 1, 2001·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Y L HeR Hori
Feb 1, 1993·Journal of Pharmacokinetics and Biopharmaceutics·A Maïza, P T Daley-Yates
Apr 1, 1991·Journal of Pharmacokinetics and Biopharmaceutics·A Maiza, P T Daley-Yates
Jan 1, 1985·CRC Critical Reviews in Toxicology·P H Bach, J W Bridges
Jan 1, 1985·Critical Reviews in Toxicology·P H Bach, J W Bridges
Mar 21, 1998·Toxicologic Pathology·J W Verlander
Mar 21, 1998·Toxicologic Pathology·P H Bach, T K Nguyen

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