PMID: 696307Sep 1, 1978Paper

Renal functional adaptation in the remnant kidney in patients with renal agenesis and in patients nephrectomized in childhood

Acta paediatrica Scandinavica
A AperiaP Wilton

Abstract

The renal response to volume expansion was determined in four patients with renal hypertrophy due to unilateral renal agenesis (URA) and in four patients with renal hypertrophy due to nephrectomy (Nz). Four healthy controls were also studied. The studies were performed during water diuresis and following i.v. infusion of isotonic saline solution. Conventional clearance techniques were used. GFR and PAH clearence were increased to about the same extent in Nz and in URA. Fractional Na+ excretion was highest in the Nz group and lowest in the control group. It was higher in the Nz group than in the URA group. Fractional water excretion (V/GFR) and free water clearance (CH2O) were also determined and the results indicate that the high fractional excretion of Na+ from the hypertrophied kidney can be attributed to reduced fractional reabsorption of filtrated Na+ both in the proximal and the distal tubules. The fractional Na+ reabsorption in the distal tubule appears to be higher in URA than in Nz. It is concluded that glomerular tubular balance for Na+ is more similar to that found in healthy controls if the stimulus to hypertrophy occurs prenatally than if it occurs postnatally.

References

Mar 1, 1977·Acta paediatrica Scandinavica·A AperiaP Wilton
Nov 30, 1976·European Journal of Clinical Investigation·J P Guignard, J H Dirks
May 1, 1976·The American Journal of Physiology·J P Guignard, J H Dirks
Jan 1, 1973·The Journal of Physiology·S E Dicker, D G Shirley
Mar 1, 1973·The American Journal of Physiology·E J WeinmanJ P Hayslett
Jun 1, 1973·Kidney International·M E AllisonC W Gottschalk
Dec 1, 1968·Scandinavian Journal of Clinical and Laboratory Investigation·F Kiil, B Bugge-Asperheim
Jun 1, 1969·The Journal of Clinical Investigation·J P HayslettF H Epstein
Nov 1, 1963·The American Journal of Physiology·G Peters
Jan 1, 1958·Pflügers Archiv : European journal of physiology·H H HILGERK J ULLRICH
May 1, 1945·The Journal of Clinical Investigation·H W SmithM Graber

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Citations

Jan 1, 1988·European Journal of Pediatrics·E DinkelM Ertel
Jul 1, 1987·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·G CelsiA Aperia
Apr 1, 1988·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·I WikstadA Aperia
Feb 1, 1989·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S Fotino
Feb 1, 1989·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A SchmitzK Sølling
Apr 4, 2008·American Journal of Physiology. Renal Physiology·Marc L WeberKalpna Gupta
Feb 10, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Reetu R SinghKate M Denton
Mar 1, 1985·The Journal of Urology·S AndersonB M Brenner

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