PMID: 6411400Jan 1, 1983Paper

Renal functional and metabolic studies on the role of preventive measures in experimental acute ischemic renal failure

Clinical and Experimental Dialysis and Apheresis
H J KramerK Glänzer

Abstract

In the present study 1 h of total occlusion of the left renal artery in conscious rats was chosen as experimental model of ischemic acute renal failure (ARF), while the contralateral kidney was left intact. Chronic high dietary sodium intake, acute isotonic saline infusion, or administration of saralasin did not protect from ARF. Furosemide, mannitol, and verapamil converted oliguric into non-oliguric ARF in 100%, 75%, and 60% of the animals, resp. Protection from oliguria and preservation of GFR inversely correlated with the depression of cortical ATP-concentration (control: 1.32 +/- 0.07 mumoles/g wet weight) 6 h after ischemia by 16%, 41%, and 58% in mannitol- and verapamil- treated rats and in untreated rats, resp. At this time, Na-K-ATPase enzyme activities in renal cortex and papilla were unaffected, while enzyme activity in outer medulla was suppressed from 15.4 +/- 1.4 to 9.4 +/- 1.0 mumoles Pi/mg protein h in all groups of animals. The results suggest that in this model of ARF renal ischemia not only affects cellular energy supply in renal cortex but also causes severe structural and functional impairment in the outer medulla, probably leading to tubular obstruction and depression of glomerular function. Pharmacologica...Continue Reading

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Citations

Jan 1, 1996·Transplant International : Official Journal of the European Society for Organ Transplantation·M L NicholsonP R Bell
Feb 15, 1990·Klinische Wochenschrift·G Kehrer, H J Bretschneider
Oct 1, 1984·Kidney International·M BrezisF H Epstein
Oct 1, 1993·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·C Fleck, J Heller
Mar 10, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·I R Shilliday, M E Allison
Aug 1, 1985·The Journal of Urology·G A GingrichS C Stewart
Jun 1, 1986·Drug Intelligence & Clinical Pharmacy·H J MannC A Hemstrom
Sep 16, 1985·Klinische Wochenschrift·H J Kramer
Dec 1, 1985·The Journal of Urology·L Hertle, B Garthoff

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