PMID: 9176530May 1, 1997Paper

Renal functional reserve in patients with severe chronic obstructive pulmonary disease

Thorax
R A SharkeyS J O'Neill

Abstract

Renal functional reserve is the normal increase in renal blood flow after a protein load, and reduced or absent renal functional reserve is an early index of renal impairment. Renal blood flow is frequently reduced during acute oedematous exacerbations of chronic obstructive pulmonary disease (COPD). It is possible that patients with severe COPD in the stable state may have a reduced or absent renal functional reserve which could be a factor in oedema formation. Sixteen stable patients with severe COPD and five normal controls were studied. The mean (SD) arterial oxygen and carbon dioxide tensions (PaO2, PaCO2) and forced expiratory volume in one second (FEV1) of patients with COPD were 8.1 (1.04) kPa, 6.3 (0.69) kPa, and 0.74 (0.27) 1, respectively. The pulsatility index (PI), an index of renovascular resistance, was measured non-invasively by Doppler ultrasonography at baseline and at intervals after a protein load of 250 g steak. The PI fell after the protein load in the normal subjects from 1.04 (0.19) to 0.84 (0.17), mean difference 0.20, 95% confidence interval of difference (CI) 0.14 to 0.27, p < 0.001. In the COPD group there was no change; baseline PI = 1.04 (0.16), PI after protein load = 1.08 (0.19), mean difference ...Continue Reading

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Citations

Dec 23, 2004·Respirology : Official Journal of the Asian Pacific Society of Respirology·Fisun KaradagOrhan Cildag
Nov 1, 2000·Critical Care : the Official Journal of the Critical Care Forum·R A SharkeyS J O'Neill
Dec 29, 2013·Current Opinion in Pulmonary Medicine·Douglas Mapel
Jun 24, 2016·American Journal of Respiratory and Critical Care Medicine·Faeq Husain-SyedClaudio Ronco
May 17, 2017·Geriatrics & Gerontology International·Andrea CorsonelloRaffaele Antonelli-Incalzi
May 1, 1997·Thorax·S V Baudouin
Oct 6, 2012·Respiration; International Review of Thoracic Diseases·R H J SlenterG G U Rohde
Nov 22, 2013·Respirology : Official Journal of the Asian Pacific Society of Respirology·Marie T WilliamsTanja Effing
Feb 22, 2018·Scandinavian Journal of Urology·Tarik Emre SenerOlivier Traxer
Jul 28, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Faeq Husain-SyedClaudio Ronco
Oct 20, 2019·Journal of Clinical Medicine·Ploypin LertjitbanjongWisit Kaewput
Dec 15, 2020·World Journal of Nephrology·Adeel Rafi AhmedPeter J Conlon

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