Renal glomerulogenesis in medaka fish, Oryzias latipes

Developmental Dynamics : an Official Publication of the American Association of Anatomists
Svetlana FedorovaYuko Wakamatsu

Abstract

We provide an overview of glomerulogenesis in medaka from the embryo to the adult by means of in situ hybridization with the wt1 gene as a marker as well as histology and three-dimensional images. The pronephric glomus starts to develop in the intermediate mesoderm during early somitogenesis, is completed before hatching, and persists throughout the lifetime of the fish. Within 5 days after hatching, mesonephric glomerulus formation begins in the caudomedial end of the pronephric sinus and duct area. The number of glomeruli reaches approximately 200-300 in each kidney within 2 months after hatching. wt1 expression during nephron maturation served as a marker for the formation of the mesenchymal condensate and the nephrogenic body. Existence of mesenchymal condensates and persistence of wt1 expression in the adult kidney suggest that the mesonephros retains precursor cells that may be capable of contributing to neoglomerulogenesis during adulthood.

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Citations

Feb 22, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Alan J Davidson
Feb 12, 2009·Development, Growth & Differentiation·Naoki WatanabeYuko Wakamatsu
Oct 3, 2012·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Koichiro IchimuraTomoko Obara
Nov 19, 2015·BMC Developmental Biology·Beate HoppeChristoph Englert

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