Renal growth hormone--insulin-like growth factor-I system in acute renal failure

Kidney International
T TsaoR Rabkin

Abstract

The renal growth hormone--insulin-like growth factor-I system in acute ischemic renal failure. Recovery from acute tubular necrosis (ATN) is accelerated by IGF-I therapy. Furthermore, the local renal growth hormone-IGF-I system may participate in the natural repair. We examined the IGF-I system in rat kidneys subjected to 60 minute ischemia compared to sham operated controls. Two days after injury, growth hormone receptor mRNA and IGF-I mRNA levels fell approximately 9 to 33% of control values. This was associated with a reduction in kidney immunoreactive IGF-I levels. In contrast, IGF-I receptor mRNA abundance was unchanged. However, plasma membrane IGF-I receptor binding on day 2 and day 7 was near double the control values (P < 0.01). Scatchard analysis revealed a near twofold increase in receptor number. Since receptor mRNA levels were unchanged, this implies receptor protein up-regulation. In contrast to unchanged IGF-I receptor mRNA levels, the abundance of mRNA levels of insulin-like growth factor binding proteins (IGFBP) -2, -3, -4 and -5 fell approximately 14 to 62% of control levels day 2 after injury (P < 0.05), suggesting reduced IGFBP production. Thus, the renal response to ischemic ATN, namely, low IGFBP mRNA leve...Continue Reading

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Citations

Mar 1, 1997·Kidney International·F C FervenzaR Rabkin
Aug 1, 1997·Kidney International·F W HsuR Rabkin
Dec 5, 1998·Kidney International. Supplement·A OrtizJ Egido
Jun 12, 2012·Endocrinology and Metabolism Clinics of North America·Daniela Kiepe, Burkhard Tönshoff
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Sep 15, 2000·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·G L Matejka, B A Bengtsson
May 9, 1998·Renal Failure·M M FriedlaenderR Rabkin
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Jan 16, 1999·Journal of the American Society of Nephrology : JASN·F C FervenzaR Rabkin
May 11, 1999·The Journal of Laboratory and Clinical Medicine·F C FervenzaR Rabkin

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