PMID: 6980741Jan 1, 1982Paper

Renal handling of 2'-deoxyadenosine and adenosine in humans and mice

Cancer Chemotherapy and Pharmacology
J R Kuttesch, J A Nelson

Abstract

In a child lacking adenosine deaminase and in patients treated with deoxycoformycin (a potent inhibitor of the enzyme), apparent renal secretion of 2'-deoxyadenosine (dAdo) and reabsorption of adenosine (Ado) were observed. The renal clearance of dAdo in humans was approximately five-fold that of creatinine, whereas the renal clearance of Ado was only one-fifth that of creatinine. In mice treated with deoxycoformycin, a similar paradigm was observed. Specifically, plasma levels of Ado and dAdo were elevated to detectable levels and apparent renal secretion and reabsorption of these purine nucleosides became manifest. Thus, the mouse may serve as a suitable model to study the renal handling of these two compounds. The active renal secretion of dAdo may occur because the compound has not been appreciably synthesized by mouse kidney in situ, and 'ion-trapping' of dAdo in acid urine could not explain the net secretion. The differential transport of these similar purine nucleosides suggests a very selective transport system in mammalian kidney. Although carrier-mediated, facilitated diffusion of purine nucleosides across cell membranes is a well-known ph enomenon, the present data indicate the existence of (an) active transport syst...Continue Reading

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Citations

Jan 1, 1989·Pharmacology & Therapeutics·J W Darnowski, R E Handschumacher
Nov 13, 2003·European Journal of Pharmacology·Lara M MangraviteKathleen M Giacomini
May 1, 1984·Pflügers Archiv : European journal of physiology·M Le Hir, U C Dubach
Jun 1, 1985·European Journal of Clinical Investigation·M Le Hir, U C Dubach
Jun 27, 2002·Biochimica Et Biophysica Acta·Giuseppe PizzornoRobert E Handschumacher
Apr 6, 2007·American Journal of Physiology. Renal Physiology·Vijaya L DamarajuCarol E Cass
Jan 12, 2007·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Adam N ElwiCarol E Cass
Aug 29, 2007·Journal of Physiology and Biochemistry·M Pastor-AngladaF J Casado
Feb 24, 2001·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·R GuieuB Dussol
Jan 1, 1995·Cancer Chemotherapy and Pharmacology·J A NelsonD A Wright
May 21, 2008·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Stephan A VeltkampJan H M Schellens
Apr 9, 2001·American Journal of Physiology. Renal Physiology·L M MangraviteK M Giacomini
Feb 10, 1999·The American Journal of Physiology·R ChenJ A Nelson
Jul 7, 1988·Biochimica Et Biophysica Acta·C W LeeS M Jarvis
May 21, 1992·Biochimica Et Biophysica Acta·D A GriffithS M Jarvis
Mar 23, 1992·Biochimica Et Biophysica Acta·M M GutierrezK M Giacomini

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