PMID: 8973668Dec 1, 1996Paper

Renal hemodynamic effects of lovastatin in a renal ablation model

Urology
K S HafezA C Novick

Abstract

Patients with renal mass reduction of more than 50% are at increased risk for progressive renal failure. Lipid-lowering agents have been shown to preserve renal function in various models of chronic renal failure. This study was performed to evaluate the hemodynamic effects of lovastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, in the remnant kidney model. Two groups of animals were studied. Group 1 (n = 9) served as controls and group 2 (n = 14) received lovastatin, 15 mg/kg/day orally, for 2 weeks after renal ablation. Glomerular filtration rate (GFR, inulin clearance), renal blood flow (RBF, ultrasonic flow probe), and 24-hour protein excretion were measured in anesthetized rats. Two weeks after renal ablation, GFR was 0.28 +/- 0.09 mL/min/gkw (gram kidney weight) in group 1, whereas in group 2, lovastatin preserved GFR at 0.58 +/- 0.3 mL/min/gkw (P < 0.05). RBF in group 1 was 1.2 +/- 0.2 mL/min/gkw and increased to 2.1 +/- 0.4 mL/min/gkw in group 2 (P < 0.05), representing a 43% increase. Protein excretion decreased significantly to 13 +/- 1.7 mg/24 hr in group 2. The lovastatin-treated group had a lower serum cholesterol (59 +/- 3 mg/dL versus 71 +/- 2 mg/dL, P < 0.05), but serum triglyceride levels we...Continue Reading

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Citations

Mar 15, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Stephanie H WilsonLilach O Lerman
Jan 27, 2011·Contemporary Clinical Trials·Melissa A CadnapaphornchaiRobert W Schrier
Nov 29, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ladan ZandFernando C Fervenza
Jul 5, 2012·Acta Cirúrgica Brasileira·Silvio Tucci JuniorAntonio Carlos Pereira Martins
Nov 18, 2005·Vascular Pharmacology·Sharon R InmanKyle Entenman
Apr 12, 2014·Clinical Journal of the American Society of Nephrology : CJASN·Melissa A CadnapaphornchaiRobert W Schrier
Oct 30, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M A van DijkG J Blauw
Sep 23, 2003·The American Journal of the Medical Sciences·Sharon R InmanVictoria A Lukaszek

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