PMID: 3754595Feb 1, 1986Paper

Renal hemodynamic effects of therapeutic plasma levels of sulindac sulfide during hemorrhage

Kidney International
W L HenrichW B Campbell

Abstract

There is continued debate over any renal sparing effects of sulindac (S): such a property would be of benefit and be unique among nonsteroidal anti-inflammatory drugs (NSAIDS). S undergoes a distinct metabolism whereby the active drug (sulindac sulfide (SS)) does not appear in the urine. Accordingly, we tested the effect of a plasma concentration of SS in the therapeutic range on renal blood flow (RBF), glomerular filtration rate (GFR), and renal prostaglandin (PG) concentrations during sudden renal ischemic stress. The ischemic stress was produced by a 15 to 20% reduction in arterial pressure by arterial hemorrhage (H) in four separate groups of anesthetized dogs: control, SS (0.4 mg/kg i.v. bolus followed by 0.03 mg/kg/min constant infusion), indomethacin (I, 10 mg/kg), and benoxaprofen (B, 75 mg/kg). A plasma concentration of 3.69 micrograms/ml of SS was achieved by the infusion, and no SS appeared in the urine. H reduced GFR (by 46%) and RBF (by 38%) in control dogs; in SS-treated dogs, a 60% decline in GFR and a 73% decrease in RGF occurred. These decreases in renal hemodynamics in the SS group during H were significantly greater than in the control group. Further, these decrements in GFR and RBF were similar to those obse...Continue Reading

References

Feb 24, 1977·The New England Journal of Medicine·R P Kimberly, P H Plotz
Jan 1, 1985·Kidney International·D C BraterW B Campbell
Mar 1, 1984·The New England Journal of Medicine·D M Clive, J S Stoff
Jan 1, 1984·Annual Review of Medicine·M J Dunn
Oct 1, 1984·Archives of Internal Medicine·W B ReevesE J Weinman
Mar 9, 1984·JAMA : the Journal of the American Medical Association·R W Schrier, W L Henrich
Jan 1, 1983·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·W L Henrich
Jun 1, 1983·Archives of Internal Medicine·J L BlackshearM T Stillman
Dec 3, 1982·JAMA : the Journal of the American Medical Association·R D Bunning, W F Barth
Oct 1, 1982·Japanese Journal of Pharmacology·S Kitamura, K Tatsumi
Mar 1, 1980·Annals of Internal Medicine·R S Muther, W M Bennett
Dec 16, 1980·Biochemical and Biophysical Research Communications·M W AndersJ A Fuchs

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Citations

Sep 1, 1993·Kidney International·D Schlondorff
Jul 1, 1987·Kidney International·C Patrono, M J Dunn
Dec 4, 2012·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Mohanad ZbidahFlorian Lang

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