Renal histology in diabetic nephropathy predicts progression to end-stage kidney disease but not the rate of renal function decline.

BMC Nephrology
Paraish S MisraDarren A Yuen

Abstract

While histopathologic changes correlate with functional impairment in cross-sectional studies of diabetic nephropathy (DN), whether these findings predict future rate of kidney function loss remains uncertain. We thus sought to examine the relationship between kidney histopathology, incidence of end-stage kidney disease (ESKD), and rate of estimated glomerular filtration rate (eGFR) loss in DN. In this longitudinal cohort study, we studied 50 adults diagnosed with biopsy-proven DN. We analyzed the histopathologic parameters of each patient's kidney biopsy, as defined by the Renal Pathology Society classification system for DN, and tracked all available eGFR measurements post-biopsy. We additionally collected baseline clinical parameters (at the time of biopsy), including eGFR, albumin-to-creatinine ratio (ACR), and hemoglobin A1c. Multivariable linear regression was used to assess the relationship between histologic and clinical parameters at the time of the biopsy and eGFR slope. Kaplan-Meier curves and Cox regression were used to evaluate the association between histologic and clinical parameters and ESKD incidence. Progression to ESKD was associated with worsening interstitial fibrosis score (p = 0.05), lower baseline eGFR (...Continue Reading

References

Mar 28, 2003·Journal of the American Society of Nephrology : JASN·Behzad NajafianMichael Mauer
Mar 28, 2006·Journal of the American Society of Nephrology : JASN·Behzad NajafianMichael Mauer
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
May 16, 2009·Journal of the American Society of Nephrology : JASN·Toshiharu NinomiyaUNKNOWN ADVANCE Collaborative Group
Aug 29, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Hiroki YokoyamaMasakazu Haneda
Feb 20, 2010·Journal of the American Society of Nephrology : JASN·Thijs W Cohen TervaertUNKNOWN Renal Pathology Society
Jan 28, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Giacomo ZoppiniEnzo Bonora
Apr 24, 2012·Diabetes Research and Clinical Practice·Se Won OhHo Jun Chin
Oct 15, 2013·Seminars in Nephrology·Susanne B NicholasKeith C Norris
Oct 24, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Koki MiseKenmei Takaichi
Jun 14, 2014·Journal of the American Society of Nephrology : JASN·Ian H de BoerUNKNOWN Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Research Group
Jul 27, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Yu AnZhihong Liu
Nov 14, 2016·Journal of Diabetes and Its Complications·Li LiFang Liu
Feb 2, 2017·Clinical Diabetes : a Publication of the American Diabetes Association·UNKNOWN American Diabetes Association
Apr 4, 2017·Kidney International·Andrzej S KrolewskiJames H Warram
Nov 21, 2017·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Misghina WeldegiorgisHiddo J L Heerspink
Nov 29, 2017·Journal of the American Society of Nephrology : JASN·Amy K MottlJ Charles Jennette

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Methods Mentioned

BETA
biopsy
biopsies
electron microscopy

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