Renal Histology in Diabetic Patients

Saudi Journal of Medicine & Medical Sciences
Yassir ZajjariDriss El Kabbaj

Abstract

The diagnosis of diabetic nephropathy is based on the course of clinical manifestations and renal biopsy. Renal biopsy is usually performed in patients with atypical presentations. This study was performed to analyze various renal histopathological lesions in diabetic patients and to establish a clinicopathological correlation. In this retrospective study, the authors analyzed renal histology of 40 patients with type 2 diabetes mellitus who presented with atypical features of diabetic renal involvement and underwent renal biopsy at the Military Hospital Mohammed V, Rabat, Morocco, between January 2008 and December 2016. About 60% of the patients had isolated diabetic nephropathy, 35% had isolated nondiabetic renal diseases and 5% had both. Patients with nondiabetic renal diseases had significantly higher hematuria (P = 0.02), shorter duration of diabetes (P = 0.009), higher mean estimated glomerular filtration rate (P = 0.04) and lower prevalence of diabetic retinopathy (P < 0.001). The most common histological lesion in patients with nondiabetic renal diseases was IgA nephropathy (25%). In patients with diabetic nephropathy, the most common histological class was Class III (42.3%). Furthermore, higher histological classes were...Continue Reading

Citations

Aug 7, 2020·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Xue TongHongtao Yang

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Methods Mentioned

BETA
biopsy
light
electron microscopy
biopsies

Software Mentioned

SPSS

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