PMID: 2835848Jan 1, 1988

Renal hypercalciuria and metabolic acidosis associated with medullary sponge kidney: effect of alkali therapy

Urological Research
E HigashiharaT Niijima

Abstract

Sixteen patients with medullary sponge kidney (MSK) and renal stones underwent evaluation of calcium metabolism and acid base balance. Six normal subjects and eight patients with non-MSK absorptive hypercalciuria served as control. Nine (56%) were hypercalciuric and seven (44%) were normocalciuric (N-MSK). Hypercalciuria was divided into absorptive (AH-MSK, n = 2) and renal leak hyerpcalciuria (RH-MSK, n = 7). The mean of minimal urine pH of RH-MSK group (5.28 +/- 0.09 (SE] was significantly higher than that of normal control (4.78 +/- 0.12) and of non-MSK AH (4.80 +/- 0.6) during acute acid challenge. The mean of the arterial blood HCO3 concentration of RH-MSK group was significantly lower than that of two control groups. The urine calcium and a frequency of stone passage were decreased significantly after alkali treatment in RH-MSK.

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Citations

Jan 1, 1994·International Urology and Nephrology·J UozumiJ Kumazawa
Dec 12, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Antonia FabrisGiovanni Gambaro
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Oct 8, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Antonia FabrisGiovanni Gambaro
Aug 5, 2017·Clinical Journal of the American Society of Nephrology : CJASN·Nasser A DhayatDaniel G Fuster
Apr 1, 1989·The Journal of Urology·K NutaharaT Niijima

Related Concepts

Anion Gap
Metabolic Acidosis
Cyclic AMP, (R)-Isomer
Carbonic Acid Ions
Calcium
Kidney Calculi
Medullary Sponge Kidney
Orthophosphate
Sodium
Sodium Bicarbonate

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